Lonodelestat, also known as POL6014, is a potent, selective inhibitor of human neutrophil elastase (NE). Preclinical studies in animals demonstrated that the investigational NE inhibitor could reduce inflammatory markers and the number of neutrophils. POL6014 significantly improves RVP and attenuates right ventricular hypertrophy in a rat MCT-induced PAH model after chronic IT administration. POL6014 at 0.3 mg/kg is as efficient as Tadalafil at 10 mg/kg. The PEM NE inhibitor POL6014 may thus provide another therapeutic treatment option for PAH.
MedKoo Cat#: 556156
Name: Lonodelestat
CAS#: 906547-89-5
Chemical Formula: C71H111N15O19
Exact Mass: 1477.8181
Molecular Weight: 1478.76
Elemental Analysis: C, 57.67; H, 7.57; N, 14.21; O, 20.56
The following data is based on the product molecular weight 1,478.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
