SR10221 | CAS# 1415321-64-0 | PPARγ Inverse Agonist

MedKoo Cat#: 121219 | Name: SR10221

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR10221 is a PPARγ inverse-agonist. SR10221 represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines.

Chemical Structure

SR10221

CAS#1415321-64-0

Theoretical Analysis

MedKoo Cat#: 121219

Name: SR10221

CAS#: 1415321-64-0

Chemical Formula: C33H37ClN2O4

Exact Mass: 560.2442

Molecular Weight: 561.12

Elemental Analysis: C, 70.64; H, 6.65; Cl, 6.32; N, 4.99; O, 11.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

SR10221; SR-10221; SR 10221;

IUPAC/Chemical Name

(S)-2-(5-((5-(((S)-1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-2-chlorophenoxy)propanoic acid

InChi Key

NPMSSJHJPGMEJW-UNMCSNQZSA-N

InChi Code

InChI=1S/C33H37ClN2O4/c1-19-21(3)36(18-23-8-14-28(34)30(16-23)40-22(4)32(38)39)29-15-11-25(17-27(19)29)31(37)35-20(2)24-9-12-26(13-10-24)33(5,6)7/h8-17,20,22H,18H2,1-7H3,(H,35,37)(H,38,39)/t20-,22-/m0/s1

SMILES Code

CC1=C(C)N(CC2=CC(O[C@@H](C)C(O)=O)=C(Cl)C=C2)C(C1=C3)=CC=C3C(N[C@@H](C)C4=CC=C(C(C)(C)C)C=C4)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 561.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Irwin S, Karr C, Furman C, Tsai J, Gee P, Banka D, Wibowo AS, Dementiev AA, O'Shea M, Yang J, Lowe J, Mitchell L, Ruppel S, Fekkes P, Zhu P, Korpal M, Larsen NA. Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists. J Biol Chem. 2022 Sep 28;298(11):102539. doi: 10.1016/j.jbc.2022.102539. Epub ahead of print. PMID: 36179791; PMCID: PMC9626935.