Propargyl-PEG4-Sulfone-PEG4-t-butyl ester is a PEG linker containing a propargyl group and t-butyl protected carboxyl group acid. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. The protected acid can be deprotected by acidic or basic hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media.
MedKoo Cat#: 122033
Name: Propargyl-PEG4-Sulfone-PEG4-t-butyl ester
CAS#: 2055024-43-4
Chemical Formula: C26H48O12S
Exact Mass: 584.2866
Molecular Weight: 584.72
Elemental Analysis: C, 53.41; H, 8.27; O, 32.83; S, 5.48
The following data is based on the product molecular weight 584.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
