MedKoo Cat#: 121173 | Name: BQN00602
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BQN00602 is a ProTAC building block. BQN00602 enables the synthesis of molecules for targeterd protein degradation. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

BQN00602
BQN00602
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 121173

Name: BQN00602

CAS#: Unknown

Chemical Formula: C30H40ClN5O4S

Exact Mass: 601.2490

Molecular Weight: 602.19

Elemental Analysis: C, 59.84; H, 6.70; Cl, 5.89; N, 11.63; O, 10.63; S, 5.32

Price and Availability

Size Price Availability Quantity
50mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
VH032 conjugate; BQN00602; BQN-00602; BQN 00602
IUPAC/Chemical Name
(2S,4R)-1-((S)-3,3-Dimethyl-2-(3-(piperidin-4-yl)propiolamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
InChi Key
BLUYAMHRXQYAKB-QVRKWNSCSA-N
InChi Code
InChI=1S/C30H39N5O4S.ClH/c1-19-26(40-18-33-19)22-8-5-21(6-9-22)16-32-28(38)24-15-23(36)17-35(24)29(39)27(30(2,3)4)34-25(37)10-7-20-11-13-31-14-12-20;/h5-6,8-9,18,20,23-24,27,31,36H,11-17H2,1-4H3,(H,32,38)(H,34,37);1H/t23-,24+,27-;/m1./s1
SMILES Code
CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C#CC4CCNCC4)=O)C(C)(C)C)=O)=O)C=C2.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 602.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL