AW-464 is a novel thioredoxin inhibitor which was found to target the thioredoxin system in a cell-free assay. In HL-60 leukaemia cells, it was also found to induce Bak activation, cytochrome c release from mitochondria, decreasing Delta Psi m, chromatin condensation, phosphatidyl serine exposure and Tdt-sensitive DNA nicks.
MedKoo Cat#: 208546
Name: AW-464
CAS#: 485842-97-5
Chemical Formula: C13H9NO2S
Exact Mass: 243.0354
Molecular Weight: 243.28
Elemental Analysis: C, 64.18; H, 3.73; N, 5.76; O, 13.15; S, 13.18
The following data is based on the product molecular weight 243.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
