Synonym
ALB 109564(a). Vincaleukoblastine 12(methylthio) hydrochloride (1:2).
IUPAC/Chemical Name
(3aR,3a1R,4R,5S,5aR,10bR)-methyl 4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-13-(methylthio)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate.
InChi Key
JICBRHIOKVTMPJ-NEJRMLFWSA-N
InChi Code
InChI=1S/C47H60N4O9S/c1-9-43(55)23-28-24-46(41(53)58-6,37-30(14-18-50(25-28)26-43)31-20-29(61-8)12-13-34(31)48-37)33-21-32-35(22-36(33)57-5)49(4)39-45(32)16-19-51-17-11-15-44(10-2,38(45)51)40(60-27(3)52)47(39,56)42(54)59-7/h11-13,15,20-22,28,38-40,48,55-56H,9-10,14,16-19,23-26H2,1-8H3/t28-,38+,39-,40-,43+,44-,45-,46+,47+/m1/s1
SMILES Code
O=C([C@]1(O)[C@]2([H])N(C)C3=C(C=C([C@@]4(C(OC)=O)C[C@@]5([H])C[C@@](O)(CC)C[N@](C5)CCC6=C4NC7=C6C=C(SC)C=C7)C(OC)=C3)[C@]2(CCN8CC=C9)[C@]8([H])[C@]9(CC)[C@H]1OC(C)=O)OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related:
1300114-12-8 (ALB-109564 dihydrochloride)
854756-74-4 (ALB-109564).
ALB 109564(a) is a novel analog from an established and marketed class of tubulin inhibitors, which is designed to kill cancer cells by preventing cell mitosis. In preclinical testing, the compound has a broad-spectrum effect in animal models, with efficacy superior to vinorelbine. Significant tumor growth delay was seen against human colon, lung and prostate solid tumors (as xenografts in mice) and against leukemia in mice. (source: http://www.amriglobal.com/pipeline/subpage.cfm?ID=19&subID=32).
ALB 109564(a) is an antimitotic agent and a semi-synthetic derivative of a natural product originally extracted from the Madagascar periwinkle flower. Antimitotic agents, used alone or most commonly in combination, continue to be an important part of cancer therapy; AMRI's tubulin inhibitor has potential to broaden this current arsenal. (source: http://www.amriglobal.com/pipeline/subpage.cfm?ID=19&subID=32).
Structures were from: AMRI 's website.
