Synonym
Plicatin B acrylate,
IUPAC/Chemical Name
2-Propenoic acid, 3-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-, methyl ester, (E)-
InChi Key
LZEOAWXRNGQEHO-RMKNXTFCSA-N
InChi Code
InChI=1S/C15H18O3/c1-11(2)4-7-13-10-12(5-8-14(13)16)6-9-15(17)18-3/h4-6,8-10,16H,7H2,1-3H3/b9-6+
SMILES Code
O=C(OC)/C=C/C1=CC=C(O)C(C/C=C(C)\C)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
246.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Eventi A, Lubrano V, Scarpato R, Turchi G. Protective effects of plicatin B on micronucleus induction in cultured human lymphocytes by different mutagens. Food Chem Toxicol. 2009 Jan;47(1):124-8. doi: 10.1016/j.fct.2008.10.017. Epub 2008 Nov 1. PMID: 19007843.
2: Lubrano V, Boni G, L'Abbate A, Turchi G. Antioxidant activity of plicatin B on cultured human microvascular endothelial cells exposed to H2O2. Drug Chem Toxicol. 2007;30(4):311-25. doi: 10.1080/01480540701522148. PMID: 17934921.
3: Nesti C, Trippi F, Scarpato R, Migliore L, Turchi G. Cytokinesis-block micronucleus assay in primary human liver fibroblasts exposed to griseofulvin and mitomycin C. Mutagenesis. 2000 Mar;15(2):143-7. doi: 10.1093/mutage/15.2.143. PMID: 10719040.
4: Maurich T, Pistelli L, Turchi G. Anti-clastogenic activity of two structurally related pterocarpans purified from Bituminaria bituminosa in cultured human lymphocytes. Mutat Res. 2004 Jul 11;561(1-2):75-81. doi: 10.1016/j.mrgentox.2004.03.006. PMID: 15238232.
5: Turchi G, Alagona G, Lubrano V. Protective activity of plicatin B against human LDL oxidation induced in metal ion-dependent and -independent processes. Experimental and theoretical studies. Phytomedicine. 2009 Nov;16(11):1014-26. doi: 10.1016/j.phymed.2009.03.018. Epub 2009 May 8. PMID: 19427772.
6: Maurich T, Iorio M, Chimenti D, Turchi G. Erybraedin C and bitucarpin A, two structurally related pterocarpans purified from Bituminaria bituminosa, induced apoptosis in human colon adenocarcinoma cell lines MMR- and p53-proficient and -deficient in a dose-, time-, and structure-dependent fashion. Chem Biol Interact. 2006 Feb 1;159(2):104-16. doi: 10.1016/j.cbi.2005.10.103. Epub 2005 Nov 3. PMID: 16271357.
7: Scarpato R, Gambacciani C, Svezia B, Chimenti D, Turchi G. Cytotoxicity and genotoxicity studies of two free-radical generators (AAPH and SIN-1) in human microvascular endothelial cells (HMEC-1) and human peripheral lymphocytes. Mutat Res. 2011 May 18;722(1):69-77. doi: 10.1016/j.mrgentox.2011.03.015. Epub 2011 Apr 8. PMID: 21497204.
8: Bertacca A, Cini M, Sbrana M, Turchi G. 3-isobutyl-1-methylxanthine inhibits the mutagenic activity of 7,12-dimethylbenz[a]anthracene in epithelial liver cells in culture. Mutat Res. 1994 Mar;323(3):127-31. doi: 10.1016/0165-7992(94)90086-8. PMID: 7509027.
9: Sbrana I, Puliti A, Seidel A, Glatt H, Turchi G. Induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells in culture by pyrene and benzo[a]pyrene quinones. Mutagenesis. 1995 Nov;10(6):505-12. doi: 10.1093/mutage/10.6.505. PMID: 8596469.
10: Camici M, Turriani M, Turchi G, Tozzi MG, Cos J, Alemany C, Noe V, Ciudad CJ. Cytotoxicity of deoxycoformycin on human colon carcinoma cell lines. Adv Exp Med Biol. 1994;370:275-8. doi: 10.1007/978-1-4615-2584-4_58. PMID: 7660907.
