Synonym
Phenyl-alpha-L-iduronide, PLIDN
IUPAC/Chemical Name
alpha-L-Idopyranosiduronic acid, phenyl
InChi Key
WVHAUDNUGBNUDZ-DSPMHBFJSA-N
InChi Code
InChI=1S/C12H14O7/c13-7-8(14)10(11(16)17)19-12(9(7)15)18-6-4-2-1-3-5-6/h1-5,7-10,12-15H,(H,16,17)/t7-,8-,9+,10+,12+/m0/s1
SMILES Code
O[C@H]([C@H]([C@@H]([C@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
270.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Butterworth J, Broadhead DM. Comparison of the substrate 4-methylumbelliferyl-alpha-l-iduronide with phenyl-alpha-L-iduronide for the diagnosis of Hurler's disease in cultured cells. J Inherit Metab Dis. 1980;2(3):71-4. doi: 10.1007/BF01801722. PMID: 6796763.
2: Hopwood JJ, Muller V, Smithson A, Baggett N. A fluorometric assay using 4-methylumbelliferyl alpha-L-iduronide for the estimation of alpha-L-iduronidase activity and the detection of Hurler and Scheie syndromes. Clin Chim Acta. 1979 Mar 1;92(2):257-65. doi: 10.1016/0009-8981(79)90121-9. PMID: 114339.
3: Den Tandt WR, Scharpe S. Characteristics of leukocyte and plasma methylumbelliferyl-alpha-L-iduronide iduronidase. Biochem Med Metab Biol. 1989 Feb;41(1):18-24. doi: 10.1016/0885-4505(89)90003-0. PMID: 2713148.
4: Hopwood JJ, Muller V. Diagnostic enzymology of alpha-L-iduronidase with special reference to a sulphated disaccharide derived from heparin. Clin Sci (Lond). 1982 Feb;62(2):193-201. doi: 10.1042/cs0620193. PMID: 6895615.
5: Kosaka H, Isemura M, Ono T, Nishimura Y, Kato K. Studies on the alpha-L- iduronidase activity of beta-glucuronidase preparations from bovine liver, rat liver, and rat preputial gland. J Biochem. 1980 Jul;88(1):69-75. PMID: 7410341.
6: Schuchman EH, Guzman NA, Takada G, Desnick RJ. Human alpha-L-iduronidase. II. Comparative biochemical and immunologic properties of the purified low and high uptake forms. Enzyme. 1984;31(3):166-75. PMID: 6734578.
7: Kleijer WJ, Thompson EJ, Niermeijer MF. Prenatal diagnosis of the Hurler syndrome: report on 40 pregnancies at risk. Prenat Diagn. 1983 Jul;3(3):179-86. doi: 10.1002/pd.1970030302. PMID: 6413967.
8: Kleijer WJ, Hensing-Wolffers GM, Thompson EJ, Niermeijer MF. The Hurler syndrome: detection of patients and heterozygotes using a microassay for alpha- L-iduronidase in fibroblasts. Clin Chim Acta. 1981 Oct 8;116(1):47-54. doi: 10.1016/0009-8981(81)90167-4. PMID: 6797759.
