UAWJ-247 | CAS# 1802664-84-1 | SARS-CoV-2 Main Protease inhibitor

MedKoo Cat#: 121130 | Name: UAWJ-247

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UAWJ-247 is a SARS-CoV-2 Main Protease inhibitor (IC50 = 45 nM).

Chemical Structure

UAWJ-247

CAS#1802664-84-1

Theoretical Analysis

MedKoo Cat#: 121130

Name: UAWJ-247

CAS#: 1802664-84-1

Chemical Formula: C24H28N3NaO8S

Exact Mass: 541.1495

Molecular Weight: 541.55

Elemental Analysis: C, 53.23; H, 5.21; N, 7.76; Na, 4.25; O, 23.63; S, 5.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

UAWJ247; UAWJ-247; UAWJ 247

IUPAC/Chemical Name

sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propane-1-sulfonate

InChi Key

VFYODHDNARQKEF-SJZJPLIYSA-M

InChi Code

InChI=1S/C24H29N3O8S.Na/c28-21-18(11-12-25-21)14-20(23(30)36(32,33)34)26-22(29)19(13-16-7-3-1-4-8-16)27-24(31)35-15-17-9-5-2-6-10-17;/h1-10,18-20,23,30H,11-15H2,(H,25,28)(H,26,29)(H,27,31)(H,32,33,34);/q;+1/p-1/t18-,19-,20-,23?;/m0./s1

SMILES Code

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C[C@@H]2CCNC2=O)C(O)S(=O)(O[Na])=O)=O)OCC3=CC=CC=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 541.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Sacco MD, Ma C, Lagarias P, Gao A, Townsend JA, Meng X, Dube P, Zhang X, Hu Y, Kitamura N, Hurst B, Tarbet B, Marty MT, Kolocouris A, Xiang Y, Chen Y, Wang J. Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L. bioRxiv [Preprint]. 2020 Jul 27:2020.07.27.223727. doi: 10.1101/2020.07.27.223727. Update in: Sci Adv. 2020 Nov 6;: PMID: 32766590; PMCID: PMC7402059.