MedKoo Cat#: 121127 | Name: LN5972

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LN5972 is a ACKR3/CXCR7 Superagonist for Platelet Degranulation Modulation. LN5972 effectively reduced P-selectin expression by up to 97%, suggesting to be a potential candidate for the treatment of platelet-mediated thrombosis.

Chemical Structure

LN5972
LN5972
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 121127

Name: LN5972

CAS#: Unknown

Chemical Formula: C19H30N6O3S

Exact Mass: 422.2100

Molecular Weight: 422.55

Elemental Analysis: C, 54.01; H, 7.16; N, 19.89; O, 11.36; S, 7.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
LN5972; LN-5972; LN 5972
IUPAC/Chemical Name
tert-butyl 4-(3-((7-ethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino)propyl)piperazine-1-carboxylate
InChi Key
MMDCWCSFXQAKSC-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H30N6O3S/c1-5-14-13-15(26)25-17(21-14)29-16(22-25)20-7-6-8-23-9-11-24(12-10-23)18(27)28-19(2,3)4/h13H,5-12H2,1-4H3,(H,20,22)
SMILES Code
CC(C)(C)OC(N(CC1)CCN1CCCNC2=NN3C(C=C(CC)N=C3S2)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 422.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Bayrak A, Mohr F, Kolb K, Szpakowska M, Shevchenko E, Dicenta V, Rohlfing AK, Kudolo M, Pantsar T, Günther M, Kaczor AA, Poso A, Chevigné A, Pillaiyar T, Gawaz M, Laufer SA. Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation. J Med Chem. 2022 Sep 23. doi: 10.1021/acs.jmedchem.2c01198. Epub ahead of print. PMID: 36150079.