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MedKoo Cat#: 208475 | Name: Lacripep

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at the extracellular domain of syndecan-1.

Chemical Structure

Lacripep
Lacripep
CAS#2243095-21-6

Theoretical Analysis

MedKoo Cat#: 208475

Name: Lacripep

CAS#: 2243095-21-6

Chemical Formula: C106H167N27O29

Exact Mass: 2282.2423

Molecular Weight: 2283.66

Elemental Analysis: C, 55.75; H, 7.37; N, 16.56; O, 20.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
IUPAC/Chemical Name
Ac-Lys-Gln-Phe-Ile-Glu-Asn-Gly-Ser-Glu-Phe-Ala-Gln-Lys-Leu-Leu-Lys-Lys-Phe-Ser-NH2
InChi Key
LQIGMWPYUDATJX-GKKSKUFBSA-N
InChi Code
InChI=1S/C106H167N27O29/c1-9-60(6)88(133-104(160)78(53-65-31-17-12-18-32-65)130-97(153)71(38-42-83(112)138)123-92(148)66(117-62(8)136)33-19-23-45-107)106(162)125-73(40-44-87(143)144)99(155)131-79(54-84(113)139)91(147)115-55-85(140)118-81(57-135)105(161)124-72(39-43-86(141)142)98(154)128-76(51-63-27-13-10-14-28-63)100(156)116-61(7)90(146)119-70(37-41-82(111)137)96(152)121-68(35-21-25-47-109)94(150)126-75(50-59(4)5)102(158)127-74(49-58(2)3)101(157)122-67(34-20-24-46-108)93(149)120-69(36-22-26-48-110)95(151)129-77(52-64-29-15-11-16-30-64)103(159)132-80(56-134)89(114)145/h10-18,27-32,58-61,66-81,88,134-135H,9,19-26,33-57,107-110H2,1-8H3,(H2,111,137)(H2,112,138)(H2,113,139)(H2,114,145)(H,115,147)(H,116,156)(H,117,136)(H,118,140)(H,119,146)(H,120,149)(H,121,152)(H,122,157)(H,123,148)(H,124,161)(H,125,162)(H,126,150)(H,127,158)(H,128,154)(H,129,151)(H,130,153)(H,131,155)(H,132,159)(H,133,160)(H,141,142)(H,143,144)/t60-,61-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,88-/m0/s1
SMILES Code
O=C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 2,283.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tauber J, Laurie GW, Parsons EC, Odrich MG; Lacripep study group*; Lacripep study group*. Lacripep for the Treatment of Primary Sjögren's-Associated Ocular Surface Disease: Results of the First-In-Human Study. Cornea. 2022 Aug 3. doi: 10.1097/ICO.0000000000003091. Epub ahead of print. PMID: 35942530. 2: Lee C, Edman MC, Laurie GW, Hamm-Alvarez SF, MacKay JA. Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium. Int J Mol Sci. 2020 Aug 26;21(17):6157. doi: 10.3390/ijms21176157. PMID: 32859014; PMCID: PMC7504496. 3: Efraim Y, Chen FYT, Cheong KN, Gaylord EA, McNamara NA, Knox SM. A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration. Cell Rep. 2022 Aug 30;40(9):111307. doi: 10.1016/j.celrep.2022.111307. PMID: 36044852.

View History

IMET-3943

IMET-3943