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MedKoo Cat#: 208461 | Name: CFT7455

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CFT7455 is a novel thalidomide analog and an immunomodulatory drug. It is a CRBN E3 ubiquitin ligase modulator

Chemical Structure

CFT7455
CFT7455
CAS# 2504235-67-8

Theoretical Analysis

MedKoo Cat#: 208461

Name: CFT7455

CAS#: 2504235-67-8

Chemical Formula: C28H27N3O4

Exact Mass: 469.2002

Molecular Weight: 469.54

Elemental Analysis: C, 71.62; H, 5.80; N, 8.95; O, 13.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CFT-7455; Cemsidomide
IUPAC/Chemical Name
(3S)-3-[6-[[4-(Morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione
InChi Key
MUKCJOOKCZSQNW-DEOSSOPVSA-N
InChi Code
InChI=1S/C28H27N3O4/c32-25-11-10-24(27(33)29-25)31-23-9-8-20(21-2-1-3-22(26(21)23)28(31)34)16-18-4-6-19(7-5-18)17-30-12-14-35-15-13-30/h1-9,24H,10-17H2,(H,29,32,33)/t24-/m0/s1
SMILES Code
O=C([C@@H](N1C(C2=CC=CC3=C(CC4=CC=C(CN5CCOCC5)C=C4)C=CC1=C23)=O)CC6)NC6=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 469.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Fuchs O. Targeting cereblon in hematologic malignancies. Blood Rev. 2022 Jul 31:100994. doi: 10.1016/j.blre.2022.100994. Epub ahead of print. PMID: 35933246.