Synonym
Ambroxol acefyllinate
IUPAC/Chemical Name
(1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetate
InChi Key
IPUHJDQWESJTGD-PFWPSKEQSA-N
InChi Code
InChI=1S/C13H18Br2N2O.C9H10N4O4/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h5-6,10-11,17-18H,1-4,7,16H2;4H,3H2,1-2H3,(H,14,15)/t10-,11-;
SMILES Code
OC(CN1C2=C(N(C)C(N(C)C2=O)=O)N=C1)=O.O[C@@H]3CC[C@@H](NCC4=C(N)C(Br)=CC(Br)=C4)CC3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
616.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kuriachan S, Amberkar MB, Mohan MK, Shahul HA, Kishore MK. Acebrophylline- induced angioedema. Indian J Pharmacol. 2015 Mar-Apr;47(2):219-20. doi: 10.4103/0253-7613.153435. PMID: 25878387; PMCID: PMC4386136.
2: Pozzi E. Acebrophylline: an airway mucoregulator and anti-inflammatory agent. Monaldi Arch Chest Dis. 2007 Jun;67(2):106-15. doi: 10.4081/monaldi.2007.498. PMID: 17695695.
3: Lohar P, Sharma MK, Sahu AK, Rathod R, Sengupta P. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672. doi: 10.1002/bmc.4672. Epub 2019 Sep 1. PMID: 31386207.
4: Tapadar SR, Das M, Chaudhuri AD, Basak S, Mahapatra AB. The Effect of Acebrophylline vs Sustained Release Theophylline in Patients of COPD- A Comparative Study. J Clin Diagn Res. 2014 Sep;8(9):MC11-4. doi: 10.7860/JCDR/2014/8176.4869. Epub 2014 Sep 20. PMID: 25386474; PMCID: PMC4225926.
5: Sharma A, Adiga S, Chogtu B, Mohapatra AK, Magazine R. Comparing the efficacy and influence on the quality of life of three classes of drugs used in bronchial asthma - a prospective study. J Clin Diagn Res. 2014 Sep;8(9):HC13-5. doi: 10.7860/JCDR/2014/8999.4877. Epub 2014 Sep 20. PMID: 25386456; PMCID: PMC4225908.
6: Agliati G. Effects of a short course of treatment with acebrophylline on the mucus rheological characteristics and respiratory function parameters in patients suffering from chronic obstructive pulmonary disease. J Int Med Res. 1996 May-Jun;24(3):302-10. doi: 10.1177/030006059602400311. PMID: 8725993.
7: Foppoli A, Zema L, Gazzaniga A, Caira MR, Nassimbeni LR, Borkum E, Bettini R, Giordano F. Solid-state chemistry of ambroxol theophylline-7-acetate. J Pharm Sci. 2007 May;96(5):1139-46. doi: 10.1002/jps.20951. PMID: 17455344.
8: Ferretti C, Coppi G, Blengio M, Genazzani E. Inhibitory effect of theophylline, theophylline-7-acetic acid, ambroxol and ambroxol- theophylline-7-acetate on rat lung cAMP phosphodiesterase isoenzymes. Int J Tissue React. 1992;14(1):31-6. PMID: 1328102.
