MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 208446 | Name: Tunicatachalcone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tunicatachalcone is a natural chalcone compound derived from Pongamia pinnata, a medicinal plant that has shown protection against neuroinflammation. Through applying mRNA transcriptomics and bioinformatics analysis, it was demonstrated that TC could mediate RIPK2-dependent gene transcription to exert the neuroprotective effect. In summary, our research presented that RIPK2 was a possible therapeutic target of TC.

Chemical Structure

Tunicatachalcone
Tunicatachalcone
CAS#329038-96-2

Theoretical Analysis

MedKoo Cat#: 208446

Name: Tunicatachalcone

CAS#: 329038-96-2

Chemical Formula: C26H30O4

Exact Mass: 406.2144

Molecular Weight: 406.52

Elemental Analysis: C, 76.82; H, 7.44; O, 15.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Tunicatachalcone;
IUPAC/Chemical Name
4-Cinnamoyl-5-hydroxy-3-methoxy-6,6-bis(3-methylbut-2-en-1-yl)cyclohexa-2,4-dien-1-one
InChi Key
LRHBSDNJSUYGFD-VAWYXSNFSA-N
InChi Code
InChI=1S/C26H30O4/c1-18(2)13-15-26(16-14-19(3)4)23(28)17-22(30-5)24(25(26)29)21(27)12-11-20-9-7-6-8-10-20/h6-14,17,29H,15-16H2,1-5H3/b12-11+
SMILES Code
O=C1C=C(OC)C(C(/C=C/C2=CC=CC=C2)=O)=C(O)C1(C/C=C(C)\C)C/C=C(C)\C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 406.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Wen R, Lv J, Jia P, Yang W, Wang N, Wu X, Xue Z, Liu Y. The protective effects of natural product tunicatachalcone against neuroinflammation via targeting RIPK2 in microglia BV-2 cells stimulated by LPS. Bioorg Med Chem. 2022 Sep 1;69:116916. doi: 10.1016/j.bmc.2022.116916. Epub 2022 Jul 2. PMID: 35792403. Andrei CC, Ferreira DT, Faccione M, de Moraes LA, de Carvalho MG, Braz-Filho R. C-prenylflavonoids from roots of Tephrosia tunicata. Phytochemistry. 2000 Dec;55(7):799-804. doi: 10.1016/s0031-9422(00)00371-x. PMID: 11190399. Yin H, Zhang S, Wu J, Nan H, Long L, Yang J, Li Q. Pongaflavanol: a prenylated flavonoid from Pongamia pinnata with a modified ring A. Molecules. 2006 Oct 20;11(10):786-91. doi: 10.3390/11100786. PMID: 17971755; PMCID: PMC6148485.