Duartin | CAS#101311-04-0 | Anti-rickettsial

MedKoo Cat#: 208438 | Name: Duartin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Duartin is an anti-rickettsial compound. These small molecules and the workflow, featuring a high-throughput phenotypic screen for growth inhibitors of intracellular Rickettsia spp. and machine learning models for the prediction of growth inhibition of an obligate intracellular Gram-negative bacterium, should prove useful in the search for new therapeutic strategies to treat infections from Rickettsia spp. and other obligate intracellular bacteria.

Chemical Structure

Duartin

CAS#101311-04-0

Theoretical Analysis

MedKoo Cat#: 208438

Name: Duartin

CAS#: 101311-04-0

Chemical Formula: C18H20O6

Exact Mass: 332.1260

Molecular Weight: 332.35

Elemental Analysis: C, 65.05; H, 6.07; O, 28.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IUPAC/Chemical Name

(3R)-3-(3-Hydroxy-2,4-dimethoxyphenyl)-8-methoxy-3,4-dihydro-2H-chromen-7-ol

InChi Key

QVVPJFBYFYYVDM-NSHDSACASA-N

InChi Code

InChI=1S/C18H20O6/c1-21-14-7-5-12(17(22-2)15(14)20)11-8-10-4-6-13(19)18(23-3)16(10)24-9-11/h4-7,11,19-20H,8-9H2,1-3H3/t11-/m0/s1

SMILES Code

OC1=C(OC)C2=C(C=C1)C[C@H](C3=CC=C(OC)C(O)=C3OC)CO2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 332.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lemenze A, Mittal N, Perryman AL, Daher SS, Ekins S, Occi J, Ahn YM, Wang X, Russo R, Patel JS, Daugherty RM, Wood DO, Connell N, Freundlich JS. Rickettsia Aglow: A Fluorescence Assay and Machine Learning Model to Identify Inhibitors of Intracellular Infection. ACS Infect Dis. 2022 Jul 8;8(7):1280-1290. doi: 10.1021/acsinfecdis.2c00014. Epub 2022 Jun 24. PMID: 35748568. 2: Inoue D, Nishijima K, Takahashi J, Yoshida Y. A delayed diagnosis of acute myeloid leukaemia during pregnancy using an old blood cell analyser. J Obstet Gynaecol. 2019 Nov;39(8):1173-1174. doi: 10.1080/01443615.2019.1600480. Epub 2019 Jun 20. PMID: 31220969. 3: Emim JA, Oliveira AB, Lapa AJ. Pharmacological evaluation of the anti- inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. J Pharm Pharmacol. 1994 Feb;46(2):118-22. doi: 10.1111/j.2042-7158.1994.tb03753.x. PMID: 8021799.