MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 121053 | Name: ASP4345

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASP4345 is a positive allosteric modulator of the dopamine type 1 (D1) receptor that selectively binds to, and enhances the activity of, D1 receptors. ASP4345 has the potential to be an effective and well-tolerated treatment option for cognitive impairment associated with schizophrenia.

Chemical Structure

ASP4345
ASP4345
CAS#1632257-75-0

Theoretical Analysis

MedKoo Cat#: 121053

Name: ASP4345

CAS#: 1632257-75-0

Chemical Formula: C19H14ClF3N4O3

Exact Mass: 438.0707

Molecular Weight: 438.79

Elemental Analysis: C, 52.01; H, 3.22; Cl, 8.08; F, 12.99; N, 12.77; O, 10.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
ASP4345; ASP-4345; ASP 4345
IUPAC/Chemical Name
2-(5-chloro-2-oxobenzo[d]oxazol-3(2H)-yl)-N-methyl-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)acetamide
InChi Key
YJODOMNPYLHYJK-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H14ClF3N4O3/c1-26(8-16-24-12-4-2-10(19(21,22)23)6-13(12)25-16)17(28)9-27-14-7-11(20)3-5-15(14)30-18(27)29/h2-7H,8-9H2,1H3,(H,24,25)
SMILES Code
ClC(C=C1)=CC(N2CC(N(C)CC3=NC4=C(C=CC(C(F)(F)F)=C4)N3)=O)=C1OC2=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 438.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Desai A, Benner L, Wu R, Gertsik L, Uz T, Marek GJ, Zhu T. Pharmacokinetics of ASP4345 from Single Ascending-Dose and Multiple Ascending-Dose Phase I Studies. Clin Pharmacokinet. 2021 Jan;60(1):79-88. doi: 10.1007/s40262-020-00911-0. PMID: 32533536; PMCID: PMC7808976.