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MedKoo Cat#: 112215 | Name: Capzimin dimer
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11.

Chemical Structure

Capzimin dimer
Capzimin dimer
CAS#2084868-04-0

Theoretical Analysis

MedKoo Cat#: 112215

Name: Capzimin dimer

CAS#: 2084868-04-0

Chemical Formula: C30H24N6O2S4

Exact Mass: 628.0844

Molecular Weight: 628.80

Elemental Analysis: C, 57.30; H, 3.85; N, 13.37; O, 5.09; S, 20.39

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Capzimin dimer
IUPAC/Chemical Name
8,8'-disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide)
InChi Key
RNEOHKZPZKEZCQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H24N6O2S4/c37-29(33-9-7-25-31-11-13-39-25)21-15-19-3-1-5-23(27(19)35-17-21)41-42-24-6-2-4-20-16-22(18-36-28(20)24)30(38)34-10-8-26-32-12-14-40-26/h1-6,11-18H,7-10H2,(H,33,37)(H,34,38)
SMILES Code
O=C(NCCC1=NC=CS1)C2=CC3=C(N=C2)C(SSC4=CC=CC5=C4N=CC(C(NCCC6=NC=CS6)=O)=C5)=CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMSO 62.9 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 628.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li J, Yakushi T, Parlati F, Mackinnon AL, Perez C, Ma Y, Carter KP, Colayco S, Magnuson G, Brown B, Nguyen K, Vasile S, Suyama E, Smith LH, Sergienko E, Pinkerton AB, Chung TDY, Palmer AE, Pass I, Hess S, Cohen SM, Deshaies RJ. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017 May;13(5):486-493. doi: 10.1038/nchembio.2326. Epub 2017 Feb 28. PMID: 28244987; PMCID: PMC5570473. 2: Moon S, Muniyappan S, Lee SB, Lee BH. Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases. Int J Mol Sci. 2021 Jun 9;22(12):6213. doi: 10.3390/ijms22126213. PMID: 34207520; PMCID: PMC8226605. 3: Lee HJ, Lee DM, Seo MJ, Kang HC, Kwon SK, Choi KS. PSMD14 Targeting Triggers Paraptosis in Breast Cancer Cells by Inducing Proteasome Inhibition and Ca2+ Imbalance. Int J Mol Sci. 2022 Feb 28;23(5):2648. doi: 10.3390/ijms23052648. PMID: 35269789; PMCID: PMC8910635. 4: Luu AK, Cadieux M, Wong M, Macdonald R, Jones R, Choi D, Oblak M, Brisson B, Sauer S, Chafitz J, Warshawsky D, Wood GA, Viloria-Petit AM. Proteomic Assessment of Extracellular Vesicles from Canine Tissue Explants as a Pipeline to Identify Molecular Targets in Osteosarcoma: PSMD14/Rpn11 as a Proof of Principle. Int J Mol Sci. 2022 Mar 17;23(6):3256. doi: 10.3390/ijms23063256. PMID: 35328679; PMCID: PMC8953151. 5: Sherman DJ, Li J. Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease. Molecules. 2020 Feb 5;25(3):671. doi: 10.3390/molecules25030671. PMID: 32033280; PMCID: PMC7037493. 6: Kumar V, Naumann M, Stein M. Computational Studies on the Inhibitor Selectivity of Human JAMM Deubiquitinylases Rpn11 and CSN5. Front Chem. 2018 Oct 9;6:480. doi: 10.3389/fchem.2018.00480. PMID: 30356695; PMCID: PMC6189316. 7: Yu W, Li J, Wang Q, Wang B, Zhang L, Liu Y, Tang M, Xu G, Yang Z, Wang X, Zhang J, Liu Y, Shi G. Targeting POH1 inhibits prostate cancer cell growth and enhances the suppressive efficacy of androgen deprivation and docetaxel. Prostate. 2019 Aug;79(11):1304-1315. doi: 10.1002/pros.23838. Epub 2019 Jun 18. PMID: 31212367. 8: Spataro V, Buetti-Dinh A. POH1/Rpn11/PSMD14: a journey from basic research in fission yeast to a prognostic marker and a druggable target in cancer cells. Br J Cancer. 2022 Sep;127(5):788-799. doi: 10.1038/s41416-022-01829-z. Epub 2022 May 2. PMID: 35501388; PMCID: PMC9428165. 9: Bustamante HA, Cereceda K, González AE, Valenzuela GE, Cheuquemilla Y, Hernández S, Arias-Muñoz E, Cerda-Troncoso C, Bandau S, Soza A, Kausel G, Kerr B, Mardones GA, Cancino J, Hay RT, Rojas-Fernandez A, Burgos PV. The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to- ER Retrograde Transport. Cells. 2020 Mar 23;9(3):777. doi: 10.3390/cells9030777. PMID: 32210007; PMCID: PMC7140897. 10: Li J, Zhang Y, Da Silva Sil Dos Santos B, Wang F, Ma Y, Perez C, Yang Y, Peng J, Cohen SM, Chou TF, Hilton ST, Deshaies RJ. Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11. Cell Chem Biol. 2018 Nov 15;25(11):1350-1358.e9. doi: 10.1016/j.chembiol.2018.07.012. Epub 2018 Aug 23. PMID: 30146242; PMCID: PMC6309308.