A-1211212 | CAS#1257044-75-9 | Inhibitor

MedKoo Cat#: 208416 | Name: A-1211212

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A-1211212 is a BCL-2 inhibitor. A-1211212 positively altered the colonic mucosa and ameliorated inflammation in mice. Pro-apoptotic BCL-2 inhibitor A-1211212 diminishes lymphocytes and ameliorates colitis in Il10-/- mice without inducing thrombocytopenia.

Chemical Structure

A-1211212

CAS#1257044-75-9

Theoretical Analysis

MedKoo Cat#: 208416

Name: A-1211212

CAS#: 1257044-75-9

Chemical Formula: C47H54ClN7O7S

Exact Mass: 895.3494

Molecular Weight: 896.50

Elemental Analysis: C, 62.97; H, 6.07; Cl, 3.95; N, 10.94; O, 12.49; S, 3.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

A1211212, A-121-1212

IUPAC/Chemical Name

2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((((1r,4r)-4-methoxycyclohexyl)methyl)amino)-3-nitrophenyl)sulfonyl)benzamide

InChi Key

CSBKUBOVPUXFLO-MAVVKCOWSA-N

InChi Code

InChI=1S/C47H54ClN7O7S/c1-47(2)18-16-34(41(27-47)32-6-8-35(48)9-7-32)30-53-20-22-54(23-21-53)36-10-14-40(44(25-36)62-38-24-33-17-19-49-45(33)51-29-38)46(56)52-63(59,60)39-13-15-42(43(26-39)55(57)58)50-28-31-4-11-37(61-3)12-5-31/h6-10,13-15,17,19,24-26,29,31,37,50H,4-5,11-12,16,18,20-23,27-28,30H2,1-3H3,(H,49,51)(H,52,56)/t31-,37-

SMILES Code

O=C(NS(C1=CC=C(NC[C@H]2CC[C@H](OC)CC2)C([N+]([O-])=O)=C1)(=O)=O)C3=C(OC4=CN=C(NC=C5)C5=C4)C=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CC(C)(C)CC7)CC6)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 896.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Weder B, Mozaffari M, Biedermann L, Mamie C, Moncsek A, Wang L, Clarke SH, Rogler G, McRae BL, Graff CL, Ruiz PA, Hausmann M. BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice. Clin Exp Immunol. 2018 Sep;193(3):346-360. doi: 10.1111/cei.13151. PMID: 29745420; PMCID: PMC6150252.