MedKoo Cat#: 112206 | Name: Corilagin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Corilagin has various anti-inflammatory and anti-cancer effects.

Chemical Structure

Corilagin
CAS#23094-69-1

Theoretical Analysis

MedKoo Cat#: 112206

Name: Corilagin

CAS#: 23094-69-1

Chemical Formula: C27H22O18

Exact Mass: 634.0806

Molecular Weight: 634.46

Elemental Analysis: C, 51.11; H, 3.50; O, 45.39

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
Corilagin; Corillagin
IUPAC/Chemical Name
14,15,16,24,25,26,53,55-octahydroxy-3,8-dioxo-53,54,55,56-tetrahydro-52H-4,7-dioxa-5(4,2)-pyrana-1,2(1,2)-dibenzenacyclooctaphane-56-yl 3,4,5-trihydroxybenzoate
InChi Key
TUSDEZXZIZRFGC-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2
SMILES Code
O=C(OCC1C(C(C(C(O1)OC(C2=CC(O)=C(C(O)=C2)O)=O)O)O3)O)C4=CC(O)=C(C(O)=C4C5=C(C(O)=C(C=C5C3=O)O)O)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
DMF 20.0 31.52
DMSO 25.0 39.40
Ethanol 25.0 39.40
PBS (pH: 7.2) 5.0 7.88
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 634.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gupta A, Singh AK, Kumar R, Ganguly R, Rana HK, Pandey PK, Sethi G, Bishayee A, Pandey AK. Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms. Molecules. 2019 Sep 19;24(18):3399. doi: 10.3390/molecules24183399. PMID: 31546767; PMCID: PMC6767293. 2: Wu C, Huang H, Choi HY, Ma Y, Zhou T, Peng Y, Pang K, Shu G, Yang X. Anti- esophageal Cancer Effect of Corilagin Extracted from Phmllanthi Fructus via the Mitochondrial and Endoplasmic Reticulum Stress Pathways. J Ethnopharmacol. 2021 Apr 6;269:113700. doi: 10.1016/j.jep.2020.113700. Epub 2020 Dec 17. PMID: 33346026. 3: Xu J, Zhang G, Tong Y, Yuan J, Li Y, Song G. Corilagin induces apoptosis, autophagy and ROS generation in gastric cancer cells in vitro. Int J Mol Med. 2019 Feb;43(2):967-979. doi: 10.3892/ijmm.2018.4031. Epub 2018 Dec 18. PMID: 30569134; PMCID: PMC6317684. 4: Tong Y, Zhang G, Li Y, Xu J, Yuan J, Zhang B, Hu T, Song G. Corilagin inhibits breast cancer growth via reactive oxygen species-dependent apoptosis and autophagy. J Cell Mol Med. 2018 Aug;22(8):3795-3807. doi: 10.1111/jcmm.13647. Epub 2018 Jun 19. PMID: 29923307; PMCID: PMC6050496. 5: Jia L, Zhou J, Zhao H, Jin H, Lv M, Zhao N, Zheng Z, Lu Y, Ming Y, Yu Y. Corilagin sensitizes epithelial ovarian cancer to chemotherapy by inhibiting Snail‑glycolysis pathways. Oncol Rep. 2017 Oct;38(4):2464-2470. doi: 10.3892/or.2017.5886. Epub 2017 Aug 7. PMID: 28791374. 6: Attar R, Cincin ZB, Bireller ES, Cakmakoglu B. Apoptotic and genomic effects of corilagin on SKOV3 ovarian cancer cell line. Onco Targets Ther. 2017 Mar 31;10:1941-1946. doi: 10.2147/OTT.S135315. PMID: 28408846; PMCID: PMC5384738. 7: Li X, Deng Y, Zheng Z, Huang W, Chen L, Tong Q, Ming Y. Corilagin, a promising medicinal herbal agent. Biomed Pharmacother. 2018 Mar;99:43-50. doi: 10.1016/j.biopha.2018.01.030. Epub 2018 Jan 8. PMID: 29324311. 8: Jia L, Jin H, Zhou J, Chen L, Lu Y, Ming Y, Yu Y. A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways. BMC Complement Altern Med. 2013 Feb 15;13:33. doi: 10.1186/1472-6882-13-33. PMID: 23410205; PMCID: PMC3598193. 9: Liu J, Qin X, Ma W, Jia S, Zhang X, Yang X, Pan D, Jin F. Corilagin induces apoptosis and autophagy in NRF2‑addicted U251 glioma cell line. Mol Med Rep. 2021 May;23(5):320. doi: 10.3892/mmr.2021.11959. Epub 2021 Mar 24. PMID: 33760110; PMCID: PMC7974271. 10: Gu Y, Xiao L, Ming Y, Zheng Z, Li W. Corilagin suppresses cholangiocarcinoma progression through Notch signaling pathway in vitro and in vivo. Int J Oncol. 2016 May;48(5):1868-76. doi: 10.3892/ijo.2016.3413. Epub 2016 Mar 2. PMID: 26935808; PMCID: PMC4809656. 11: Jin X, Fu Q, Gu Z, Zhang Z, Lv H. Injectable corilagin/low molecular weight chitosan/PLGA-PEG-PLGA thermosensitive hydrogels for localized cancer therapy and promoting drug infiltration by modulation of tumor microenvironment. Int J Pharm. 2020 Nov 15;589:119772. doi: 10.1016/j.ijpharm.2020.119772. Epub 2020 Aug 13. PMID: 32800934. 12: Deng Y, Li X, Li X, Zheng Z, Huang W, Chen L, Tong Q, Ming Y. Corilagin induces the apoptosis of hepatocellular carcinoma cells through the mitochondrial apoptotic and death receptor pathways. Oncol Rep. 2018 Jun;39(6):2545-2552. doi: 10.3892/or.2018.6396. Epub 2018 Apr 23. PMID: 29693193; PMCID: PMC5983927. 13: Qin X, Liu J, Pan D, Ma W, Cheng P, Jin F. Corilagin induces human glioblastoma U251 cell apoptosis by impeding activity of (immuno)proteasome. Oncol Rep. 2021 Apr;45(4):34. doi: 10.3892/or.2021.7985. Epub 2021 Mar 2. PMID: 33649855; PMCID: PMC7905533. 14: Qiu F, Liu L, Lin Y, Yang Z, Qiu F. Corilagin Inhibits Esophageal Squamous Cell Carcinoma by Inducing DNA Damage and Down-Regulation of RNF8. Anticancer Agents Med Chem. 2019;19(8):1021-1028. doi: 10.2174/1871520619666190307120811. PMID: 30848215. 15: Tong F, Zhang J, Liu L, Gao X, Cai Q, Wei C, Dong J, Hu Y, Wu G, Dong X. Corilagin Attenuates Radiation-Induced Brain Injury in Mice. Mol Neurobiol. 2016 Dec;53(10):6982-6996. doi: 10.1007/s12035-015-9591-6. Epub 2015 Dec 15. PMID: 26666668. 16: Lv B, Li X, Wang H. Corilagin decreases insulin resistance in polycystic ovary syndrome rat model through regulating AMPK/GSK3β pathway. Transl Cancer Res. 2020 May;9(5):3242-3248. doi: 10.21037/tcr.2020.04.27. PMID: 35117690; PMCID: PMC8798515. 17: Jia S, He D, Liang X, Cheng P, Liu J, Chen M, Wang C, Zhang H, Meng C. Corilagin induces apoptosis and inhibits autophagy of HL‑60 cells by regulating miR‑451/HMGB1 axis. Mol Med Rep. 2022 Jan;25(1):34. doi: 10.3892/mmr.2021.12550. Epub 2021 Dec 1. PMID: 34850958; PMCID: PMC8669704. 18: Zhang L, Jia B, Velu P, Wu H. Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine. Environ Toxicol. 2022 May;37(5):1222-1230. doi: 10.1002/tox.23478. Epub 2022 Feb 1. PMID: 35103375. 19: Yu X, Wu T, Liao B, Du Z, Zhu P. Anticancer potential of corilagin on T24 and TSGH 8301 bladder cancer cells via the activation of apoptosis by the suppression of NF-κB-induced P13K/Akt signaling pathway. Environ Toxicol. 2022 May;37(5):1152-1159. doi: 10.1002/tox.23472. Epub 2022 Jan 27. PMID: 35084093. 20: Yang MH, Baek SH, Hwang ST, Um JY, Ahn KS. Corilagin exhibits differential anticancer effects through the modulation of STAT3/5 and MAPKs in human gastric cancer cells. Phytother Res. 2022 Jun;36(6):2449-2462. doi: 10.1002/ptr.7419. Epub 2022 Mar 2. PMID: 35234310.