Narmafotinib (AMP-945) is a selective and potent inhibitor of focal adhesion kinase (FAK), developed for oncology and fibrosis-related indications. It targets FAK with nanomolar potency (reported IC₅₀ ~1–5 nM in biochemical assays) and exhibits high selectivity over other kinases. Preclinical studies have shown that AMP-945 effectively reduces phosphorylation of FAK and downstream signaling molecules such as paxillin and AKT in cancer cell lines and fibrotic models. In xenograft tumor models, AMP-945 has demonstrated antitumor activity, particularly when combined with chemotherapy or immune checkpoint inhibitors, supporting its role in modifying the tumor microenvironment
MedKoo Cat#: 208407
Name: Narmafotinib
CAS#: 1393653-34-3
Chemical Formula: C28H32F3N5O2
Exact Mass: 527.2508
Molecular Weight: 527.59
Elemental Analysis: C, 63.74; H, 6.11; F, 10.80; N, 13.27; O, 6.06
The following data is based on the product molecular weight 527.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
