1H-30 is a potential Topo I/COX-2 inhibitor which possesses anti-inflammatory and anticancer effects, with inhibition of the NF-κB pathway. 1H-30 showed potential anticancer effects and suppressed the activation of the NF-κB pathway in cancer cells. 1H-30 inhibited the nuclear translocation of NF-κB and suppressed the production of NO, COX-2, and IL-1β in RAW264.7. In vivo, 1H-30 showed acceptable pharmacokinetic parameters, decreased the tumor growth without affecting the body weight, down-regulated COX-2 and MMP-9, and induced apoptosis in the CT26.WT tumor-bearing mice.
MedKoo Cat#: 121033
Name: 1H-30
CAS#: Unknown
Chemical Formula: C21H18ClFN2O3
Exact Mass: 400.0990
Molecular Weight: 400.83
Elemental Analysis: C, 62.93; H, 4.53; Cl, 8.84; F, 4.74; N, 6.99; O, 11.97
The following data is based on the product molecular weight 400.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
