MS159 is a first-in-class NSD2 proteolysis targeting chimera (PROTAC) degrader, MS159 also effectively degraded CRBN neo-substrates IKZF1 and IKZF3, but not GSPT1. Moreover, MS159 was bioavailable in mice.
MedKoo Cat#: 121030
Name: MS159
CAS#: 3031353-59-7
Chemical Formula: C43H40N8O10
Exact Mass: 828.2867
Molecular Weight: 828.84
Elemental Analysis: C, 62.31; H, 4.86; N, 13.52; O, 19.30
The following data is based on the product molecular weight 828.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
