WYE-28 is a potent and selective inhibitor of the mechanistic target of rapamycin (mTOR), an essential kinase involved in regulating cell growth, proliferation, and survival. It inhibits mTOR with an IC50 of 0.08 nM and displays 75-fold selectivity over PI3Kα (IC50 = 6 nM). As an ATP-competitive inhibitor, WYE-28 binds to the catalytic site of mTOR, effectively blocking its activity
MedKoo Cat#: 471204
Name: WYE-28
CAS#: 1062172-60-4
Chemical Formula: C30H34N8O5
Exact Mass: 586.2650
Molecular Weight: 586.65
Elemental Analysis: C, 61.42; H, 5.84; N, 19.10; O, 13.64
The following data is based on the product molecular weight 586.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
