PROTAC HL-8 chemically induced degradation of PI3K kinase by hijacking VHL E3 Ubiquitin Ligase. HL-8 has a significant and complete degradation effect on PI3K kinase at a concentration of 10 μM within 8 h.
MedKoo Cat#: 208389
Name: PROTAC HL-8
CAS#: 2766352-64-9
Chemical Formula: C57H59F2N11O9S2
Exact Mass: 1143.3907
Molecular Weight: 1144.28
Elemental Analysis: C, 59.83; H, 5.20; F, 3.32; N, 13.46; O, 12.58; S, 5.60
The following data is based on the product molecular weight 1,144.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
