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MedKoo Cat#: 208388 | Name: beta-nor-Lapachone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

beta-nor-Lapachone functions as an antibiofilm agent and adjuvant on the antifungal therapy related to resistant infections caused by C. glabrata.

Chemical Structure

beta-nor-Lapachone
beta-nor-Lapachone
CAS#52436-88-1

Theoretical Analysis

MedKoo Cat#: 208388

Name: beta-nor-Lapachone

CAS#: 52436-88-1

Chemical Formula: C14H12O3

Exact Mass: 228.0786

Molecular Weight: 228.25

Elemental Analysis: C, 73.67; H, 5.30; O, 21.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
betanorLapachone, nor-beta--Lapachone
IUPAC/Chemical Name
2,2-Dimethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione
InChi Key
DMSVAEFGRLMACV-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H12O3/c1-14(2)7-10-12(16)11(15)8-5-3-4-6-9(8)13(10)17-14/h3-6H,7H2,1-2H3
SMILES Code
O=C(C(C1=C2OC(C)(C)C1)=O)C3=C2C=CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 228.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Clemente de Moraes D, do Carmo Freire Ribeiro Pinto M, Tenório Sousa Domingos L, do Valle Pereira Midlej V, Ferreira-Pereira A. Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. Bioorg Med Chem. 2022 Jun 1;63:116749. doi: 10.1016/j.bmc.2022.116749. Epub 2022 Apr 14. PMID: 35436747. Moraes DC, Curvelo JAR, Anjos CA, Moura KCG, Pinto MCFR, Portela MB, Soares RMA. β-lapachone and α-nor-lapachone modulate Candida albicans viability and virulence factors. J Mycol Med. 2018 Jun;28(2):314-319. doi: 10.1016/j.mycmed.2018.03.004. Epub 2018 Mar 26. PMID: 29598974.

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