MET409 | CAS# 2244440-85-3 | FXR agonist

MedKoo Cat#: 121023 | Name: MET409

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Omesdafexor, also known as MET409, is a FXR agonist. MET409 led to significant liver fat reduction and delivered a favorable side effect profile after 12 weeks of treatment in patients with non-alcoholic steatohepatitis.

Chemical Structure

MET409

CAS#2244440-85-3

Theoretical Analysis

MedKoo Cat#: 121023

Name: MET409

CAS#: 2244440-85-3

Chemical Formula: C34H43N3O3

Exact Mass: 541.3304

Molecular Weight: 541.74

Elemental Analysis: C, 75.38; H, 8.00; N, 7.76; O, 8.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

MET409; MET-409; MET 409; Omesdafexor;

IUPAC/Chemical Name

(1r,4R)-N-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)-4-hydroxy-N-(((1r,4R)-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)cyclohexane-1-carboxamide

InChi Key

RPBNLMPTFCTXRQ-RYYHSFPWSA-N

InChi Code

InChI=1S/C34H43N3O3/c1-23-18-28(12-17-33(23)40-2)25-8-6-24(7-9-25)21-36(34(39)26-10-15-32(38)16-11-26)31-5-3-4-27(19-31)29-20-35-37(22-29)30-13-14-30/h3-5,12,17-20,22,24-26,30,32,38H,6-11,13-16,21H2,1-2H3/t24-,25-,26-,32-

SMILES Code

CC1=C(OC)C=CC([C@@H]2CC[C@@H](CN(C([C@@H]3CC[C@@H](O)CC3)=O)C4=CC(C5=CN(C6CC6)N=C5)=CC=C4)CC2)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 541.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Harrison SA, Bashir MR, Lee KJ, Shim-Lopez J, Lee J, Wagner B, Smith ND, Chen HC, Lawitz EJ. A structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis. J Hepatol. 2021 Jul;75(1):25-33. doi: 10.1016/j.jhep.2021.01.047. Epub 2021 Feb 11. PMID: 33581174.