C5-Chem-CLIP | CAS#unknown | Cross-linker

MedKoo Cat#: 208380 | Name: C5-Chem-CLIP

Description:

WARNING: This product is for research use only, not for human or veterinary use.

C5-Chem-CLIP is a covalent molecule that validated direct target engagement and demonstrated its specificity for the viral RNA, as compared to highly expressed host mRNAs. The RIBOTAC lead optimization strategy improved the bioactivity of the compound at least 10-fold

Chemical Structure

C5-Chem-CLIP

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208380

Name: C5-Chem-CLIP

CAS#: unknown

Chemical Formula: C48H63Cl2N11O5S

Exact Mass: 975.4111

Molecular Weight: 977.06

Elemental Analysis: C, 59.01; H, 6.50; Cl, 7.26; N, 15.77; O, 8.19; S, 3.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

C5Chem-CLIP, C5-ChemCLIP, C5ChemCLIP

IUPAC/Chemical Name

N-((R)-5-(4-(4-(Bis(2-chloroethyl)amino)phenyl)butanamido)-6-oxo-6-((2-(5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)amino)hexyl)-3-((4-(methylamino)quinazolin-2-yl)amino)benzamide

InChi Key

ZSQWOHCNSOGGKC-OYSHXDRRSA-N

InChi Code

InChI=1S/C48H63Cl2N11O5S/c1-51-44-36-13-2-3-14-37(36)57-47(60-44)55-34-12-9-11-33(30-34)45(64)53-25-7-6-15-38(56-42(63)18-8-10-32-19-21-35(22-20-32)61(28-23-49)29-24-50)46(65)54-27-26-52-41(62)17-5-4-16-40-43-39(31-67-40)58-48(66)59-43/h2-3,9,11-14,19-22,30,38-40,43H,4-8,10,15-18,23-29,31H2,1H3,(H,52,62)(H,53,64)(H,54,65)(H,56,63)(H2,58,59,66)(H2,51,55,57,60)/t38-,39-,40-,43-/m1/s1

SMILES Code

O=C(NCCCC[C@@H](NC(CCCC1=CC=C(N(CCCl)CCCl)C=C1)=O)C(NCCNC(CCCC[C@H]2SC[C@@]([C@@]2([H])N3)([H])NC3=O)=O)=O)C4=CC=CC(NC5=NC(NC)=C6C=CC=CC6=N5)=C4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 977.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Haniff HS, Tong Y, Liu X, Chen JL, Suresh BM, Andrews RJ, Peterson JM, O'Leary CA, Benhamou RI, Moss WN, Disney MD. Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders. ACS Cent Sci. 2020 Oct 28;6(10):1713-1721. doi: 10.1021/acscentsci.0c00984. Epub 2020 Sep 30. PMID: 33140033; PMCID: PMC7553039.