MedKoo Cat#: 208376 | Name: Jedi1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Jedi1 is a Piezo1-activating molecule

Chemical Structure

Jedi1
Jedi1
CAS#108124-17-0

Theoretical Analysis

MedKoo Cat#: 208376

Name: Jedi1

CAS#: 108124-17-0

Chemical Formula: C12H10O3

Exact Mass: 202.0630

Molecular Weight: 202.21

Elemental Analysis: C, 71.28; H, 4.98; O, 23.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Jedi1, Jedi1
IUPAC/Chemical Name
2-Methyl-5-phenylfuran-3-carboxylic acid
InChi Key
VLMNACSEESRUAK-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H10O3/c1-8-10(12(13)14)7-11(15-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,13,14)
SMILES Code
CC(O1)=C(C(O)=O)C=C1C2=CC=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 202.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xiao B. Levering Mechanically Activated Piezo Channels for Potential Pharmacological Intervention. Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:195-218. doi: 10.1146/annurev-pharmtox-010919-023703. Epub 2019 Aug 27. PMID: 31454291. 2: Kotanko P, Jörg DJ, Grobe N, Zaba C. The Piezo1 hypothesis of renal anemia. FASEB Bioadv. 2022 May 25;4(7):436-440. doi: 10.1096/fba.2022-00024. PMID: 35812074; PMCID: PMC9254218. 3: Trevisan AJ, Bauer MB, Brindley RL, Currie KPM, Carter BD. Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism. Sci Rep. 2020 Jan 28;10(1):1300. doi: 10.1038/s41598-020-57971-2. PMID: 31992767; PMCID: PMC6987110. 4: Sullivan CS, Scheib JL, Ma Z, Dang RP, Schafer JM, Hickman FE, Brodsky FM, Ravichandran KS, Carter BD. The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism. Mol Biol Cell. 2014 Jun 15;25(12):1925-36. doi: 10.1091/mbc.E13-11-0658. Epub 2014 Apr 17. PMID: 24743597; PMCID: PMC4055271. 5: Scheib JL, Sullivan CS, Carter BD. Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through the tyrosine kinase Syk. J Neurosci. 2012 Sep 19;32(38):13022-31. doi: 10.1523/JNEUROSCI.6350-11.2012. PMID: 22993420; PMCID: PMC3464495. 6: Wu HH, Bellmunt E, Scheib JL, Venegas V, Burkert C, Reichardt LF, Zhou Z, Fariñas I, Carter BD. Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Nat Neurosci. 2009 Dec;12(12):1534-41. doi: 10.1038/nn.2446. Epub 2009 Nov 15. PMID: 19915564; PMCID: PMC2834222