BOS-318 is a highly selective, cell-permeable furin inhibitor that derives selectivity by eliciting the formation of a new, unexpected binding pocket independent of the active site catalytic triad. Using human ex vivo models, BOS-318 showed significant suppression of ENaC, which led to enhanced airway hydration and an ∼30-fold increase in MCC rate.
MedKoo Cat#: 208371
Name: BOS-318
CAS#: 2387633-15-8
Chemical Formula: C28H32Cl2N6O3
Exact Mass: 570.1913
Molecular Weight: 571.50
Elemental Analysis: C, 58.85; H, 5.64; Cl, 12.41; N, 14.71; O, 8.40
The following data is based on the product molecular weight 571.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
