Androsin | CAS#531-28-2 | Bronchial obstruction inhibitor

MedKoo Cat#: 112191 | Name: Androsin

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Androsin is a naturally occurring diterpenoid compound isolated from the marine red alga Laurencia species. It exhibits notable anti-inflammatory and antiallergic bioactivity, primarily through the inhibition of histamine release from mast cells and suppression of leukotriene production. Androsin’s mechanism of action involves modulation of intracellular calcium signaling pathways, which are critical in the degranulation process of immune cells.

Chemical Structure

Androsin

CAS#531-28-2

Theoretical Analysis

MedKoo Cat#: 112191

Name: Androsin

CAS#: 531-28-2

Chemical Formula: C15H20O8

Exact Mass: 328.1158

Molecular Weight: 328.32

Elemental Analysis: C, 54.88; H, 6.14; O, 38.98

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 550.00	2 Weeks
10mg	USD 950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Androsin

IUPAC/Chemical Name

1-(3-methoxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethan-1-one

InChi Key

QUOZWMJFTQUXON-UXXRCYHCSA-N

InChi Code

InChI=1S/C15H20O8/c1-7(17)8-3-4-9(10(5-8)21-2)22-15-14(20)13(19)12(18)11(6-16)23-15/h3-5,11-16,18-20H,6H2,1-2H3/t11-,12-,13+,14-,15-/m1/s1

SMILES Code

COC1=C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=CC(C(C)=O)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 328.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dorsch W, Stuppner H, Wagner H, Gropp M, Demoulin S, Ring J. Antiasthmatic effects of Picrorhiza kurroa: androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigs. Int Arch Allergy Appl Immunol. 1991;95(2-3):128-33. doi: 10.1159/000235416. PMID: 1718906. 2: Stuppner H, Wagner H. Minor Iridoid and Phenol Glycosides of Picrorhiza kurrooa. Planta Med. 1989 Oct;55(5):467-9. doi: 10.1055/s-2006-962066. PMID: 17262460. 3: Kim JS, Shim SH, Xu YN, Kang SS, Son KH, Chang HW, Kim HP, Bae K. Phenolic glycosides from Pyrola japonica. Chem Pharm Bull (Tokyo). 2004 Jun;52(6):714-7. doi: 10.1248/cpb.52.714. PMID: 15187393. 4: Wang H, Sun Y, Ye WC, Xiong F, Wu JJ, Yang CH, Zhao SX. Antioxidative phenylethanoid and phenolic glycosides from Picrorhiza scrophulariiflora. Chem Pharm Bull (Tokyo). 2004 May;52(5):615-7. doi: 10.1248/cpb.52.615. PMID: 15133218. 5: Sakamoto Y, Inoue N, Nakanishi Y, Ninomiya K, Yoshikawa M, Muraoka O, Manse Y, Morikawa T. Hepatoprotective Principles from the Rhizomes of Picrorhiza kurroa. Biol Pharm Bull. 2023;46(6):848-855. doi: 10.1248/bpb.b23-00167. PMID: 37258151. 6: Chen Z, Wu J, Shen W, Liu P, Cao Y, Lu Y. Counter-current chromatographic method for preparative scale isolation of picrosides from traditional Chinese medicine Picrorhiza scrophulariiflora. J Sep Sci. 2011 Aug;34(15):1910-6. doi: 10.1002/jssc.201100025. Epub 2011 Jul 1. PMID: 21721121. 7: De Rosa S, De Giulio A, Tommonaro G. Aliphatic and aromatic glycosides from the cell cultures of Lycopersicon esculentum. Phytochemistry. 1996 Jul;42(4):1031-4. doi: 10.1016/0031-9422(96)00083-0. PMID: 8688181. 8: Dorsch W, Wagner H, Neszmelyi A, Stuppner H. Acetophenones: Highly Active Antiasthmatic Compounds of Plant Origin. Int Arch Allergy Immunol. 1992;99(2-4):493-495. doi: 10.1159/000236322. Epub 2009 Sep 2. PMID: 34167259. 9: Dorsch W, Müller A, Christoffel V, Stuppner H, Antus S, Gottsegen A, Wagner H. Antiasthmatic acetophenones - an in vivo study on structure activity relationship. Phytomedicine. 1994 Jun;1(1):47-54. doi: 10.1016/S0944-7113(11)80022-X. PMID: 23195815. 10: Kim IH, Kaneko N, Uchiyama N, Lee JE, Takeya K, Kawahara N, Goda Y. Two phenylpropanoid glycosides from Neopicrorhiza scrophulariiflora. Chem Pharm Bull (Tokyo). 2006 Feb;54(2):275-7. doi: 10.1248/cpb.54.275. PMID: 16462084. 11: Monthakantirat O, De-Eknamkul W, Umehara K, Yoshinaga Y, Miyase T, Warashina T, Noguchi H. Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. J Nat Prod. 2005 Mar;68(3):361-4. doi: 10.1021/np040175c. PMID: 15787436. 12: Dorsch W, Wagner H. New antiasthmatic drugs from traditional medicine? Int Arch Allergy Appl Immunol. 1991;94(1-4):262-5. doi: 10.1159/000235378. PMID: 1937886. 13: Nan ZD, Zhao MB, Jiang Y, Tu PF. [Chemical constituents from stems of Cistanche deserticola cultured in Tarim desert]. Zhongguo Zhong Yao Za Zhi. 2013 Aug;38(16):2665-70. Chinese. PMID: 24228584. 14: Amin HIM, Hussain FHS, Najmaldin SK, Thu ZM, Ibrahim MF, Gilardoni G, Vidari G. Phytochemistry and Biological Activities of Iris Species Growing in Iraqi Kurdistan and Phenolic Constituents of the Traditional Plant Iris postii. Molecules. 2021 Jan 7;26(2):264. doi: 10.3390/molecules26020264. PMID: 33430398; PMCID: PMC7827031. 15: Gingell JC, Knönagel H, Kurth KH, Tunn UW. Placebo controlled double-blind study to test the efficacy of the aromatase inhibitor atamestane in patients with benign prostatic hyperplasia not requiring operation. The Schering 90.062 Study Group. J Urol. 1995 Aug;154(2 Pt 1):399-401. doi: 10.1097/00005392-199508000-00020. PMID: 7541854. 16: Xie GY, Chen YJ, Wen R, Xu JY, Wu SS, Qin MJ. [Chemical constituents from rhizomes of Iris germanica]. Zhongguo Zhong Yao Za Zhi. 2014 Mar;39(5):846-50. Chinese. PMID: 25204177. 17: Wu C, Wang Y, Sun H. Targeted and untargeted metabolomics reveals deep analysis of drought stress responses in needles and roots of Pinus taeda seedlings. Front Plant Sci. 2023 Jan 31;13:1031466. doi: 10.3389/fpls.2022.1031466. PMID: 36798806; PMCID: PMC9927248. 18: Xu X, Wei T, Xue Q, Ai J, Li G, Liu Z, Li D, Hou J, Jin H, Liu Y, Liang X. [Analysis on quality value transmitting of Qinggusan reference sample of classical prescription based on quantitative fingerprint technology]. Se Pu. 2023 Feb;41(2):142-151. Chinese. doi: 10.3724/SP.J.1123.2022.09024. PMID: 36725710; PMCID: PMC9892975.