MS8511 | CAS#2866408-21-9 | G9a/GLP inhibitor

MedKoo Cat#: 121007 | Name: MS8511

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MS8511 is a G9a/GLP covalent irreversible inhibitor. Compared to the noncovalent G9a/GLP inhibitor UNC0642, covalent inhibitor MS8511 displayed improved potency in enzymatic and cellular assays. MS8511 displays potential kinetic preference for covalently modifying G9a over GLP.

Chemical Structure

MS8511

CAS#2866408-21-9

Theoretical Analysis

MedKoo Cat#: 121007

Name: MS8511

CAS#: 2866408-21-9

Chemical Formula: C28H41N5O3

Exact Mass: 495.3209

Molecular Weight: 495.66

Elemental Analysis: C, 67.85; H, 8.34; N, 14.13; O, 9.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MS8511; MS-8511; MS 8511

IUPAC/Chemical Name

N-(4-((1-isopropylpiperidin-4-yl)amino)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-2-yl)acrylamide

InChi Key

FNRUPVONTWZCGL-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H41N5O3/c1-5-28(34)31-27-19-24(29-21-9-14-33(15-10-21)20(2)3)22-17-25(35-4)26(18-23(22)30-27)36-16-8-13-32-11-6-7-12-32/h5,17-21H,1,6-16H2,2-4H3,(H2,29,30,31,34)

SMILES Code

COC1=C(C=C(N=C(NC(C=C)=O)C=C2NC3CCN(C(C)C)CC3)C2=C1)OCCCN4CCCC4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 495.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Park KS, Xiong Y, Yim H, Velez J, Babault N, Kumar P, Liu J, Jin J. Discovery of the First-in-Class G9a/GLP Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10506-10522. doi: 10.1021/acs.jmedchem.2c00652. Epub 2022 Jun 28. PMID: 35763668.