DSM705 is a DHODH inhibitor. DSM705 shows good potency. DSM705 shows modest inhibition of CYP2C19 (IC50=6.3). DHODH is an essential enzyme that catalyzes the rate-limiting step of pyrimidine biosynthesis. Researchers demonstrated that resistance to DHODH inhibitors can be acquired through point mutations in the inhibitor-binding pocket or copy number variations (CNVs) at the dhodh locus. As a result,
MedKoo Cat#: 208356
Name: DSM705
CAS#: 2653225-38-6
Chemical Formula: C19H19F3N6O
Exact Mass: 404.1572
Molecular Weight: 404.40
Elemental Analysis: C, 56.43; H, 4.74; F, 14.09; N, 20.78; O, 3.96
The following data is based on the product molecular weight 404.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
