MedKoo Cat#: 208350 | Name: SR8185

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR8185 is a potent and selective TBK1 inhibitor. This inhibitor may be implicated to facilitate therapeutic management of cancer and TBK1-associated diseases in the future.

Chemical Structure

SR8185
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208350

Name: SR8185

CAS#: unknown

Chemical Formula: C26H27N7O

Exact Mass: 453.2277

Molecular Weight: 453.55

Elemental Analysis: C, 68.85; H, 6.00; N, 21.62; O, 3.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SR-8185
IUPAC/Chemical Name
N-[3-[[4-(3-Cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
InChi Key
MQAQKNLCUSPSAF-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H27N7O/c27-18-20-16-19(8-9-24(20)32-12-1-2-13-32)23-10-11-28-25(31-23)29-21-6-5-7-22(17-21)30-26(34)33-14-3-4-15-33/h5-11,16-17H,1-4,12-15H2,(H,30,34)(H,28,29,31)
SMILES Code
O=C(N1CCCC1)NC2=CC=CC(NC3=NC=CC(C4=CC=C(N5CCCC5)C(C#N)=C4)=N3)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 453.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Alam M, Ansari MM, Noor S, Mohammad T, Hasan GM, Kazim SN, Hassan MI. Therapeutic targeting of TANK-binding kinase signaling towards anticancer drug development: Challenges and opportunities. Int J Biol Macromol. 2022 May 15;207:1022-1037. doi: 10.1016/j.ijbiomac.2022.03.157. Epub 2022 Mar 28. PMID: 35358582.