NCRW0005-F05 | CAS# 342779-66-2 | GPR139 antagonist

MedKoo Cat#: 208344 | Name: NCRW0005-F05

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NCRW0005-F05 is a potent GPR139 antagonist with an IC50 value of 0.21 μM.

Chemical Structure

NCRW0005-F05

CAS# 342779-66-2

Theoretical Analysis

MedKoo Cat#: 208344

Name: NCRW0005-F05

CAS#: 342779-66-2

Chemical Formula: C16H13F2NO2

Exact Mass: 289.0914

Molecular Weight: 289.28

Elemental Analysis: C, 66.43; H, 4.53; F, 13.13; N, 4.84; O, 11.06

Price and Availability

Size	Price	Availability
25mg	USD 450.00	2 Weeks
50mg	USD 750.00	2 Weeks
100mg	USD 1,350.00	2 Weeks
200mg	USD 2,050.00	2 Weeks
500mg	USD 3,650.00	2 Weeks
1g	USD 4,950.00	2 Weeks
2g	USD 7,450.00	2 Weeks

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Related CAS #

No Data

Synonym

NCRW0005F05; NCRW0005-F05

IUPAC/Chemical Name

3,3-Difluoro-4-(4-methoxyphenyl)-1-phenylazetidin-2-one

InChi Key

AIIIYUSGINMZMS-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H13F2NO2/c1-21-13-9-7-11(8-10-13)14-16(17,18)15(20)19(14)12-5-3-2-4-6-12/h2-10,14H,1H3

SMILES Code

O=C1N(C2=CC=CC=C2)C(C3=CC=C(OC)C=C3)C1(F)F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 289.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Wang J, Zhu LY, Liu Q, Hentzer M, Smith GP, Wang MW. High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139. Acta Pharmacol Sin. 2015 Jul;36(7):874-8. doi: 10.1038/aps.2015.12. Epub 2015 Jun 1. PMID: 26027661; PMCID: PMC4648122.