CRCM5484 | CAS#unknown | Inhibitor

MedKoo Cat#: 208337 | Name: CRCM5484

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CRCM5484 A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation. CRCM5484 is a potent inhibitor of BET proteins with a preferential and 475-fold selectivity for the second bromodomain of the BRD3 protein (BRD3-BDII) over its first bromodomain (BRD3-BDI).

Chemical Structure

CRCM5484

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208337

Name: CRCM5484

CAS#: unknown

Chemical Formula: C24H23N5O4S2

Exact Mass: 509.1191

Molecular Weight: 509.60

Elemental Analysis: Chemical Formula: C24H23N5O4S2 Exact Mass: 509.1191 Molecular Weight: 509.5990 Elemental Analysis: C, 56.57; H, 4.55; N, 13.74; O, 12.56; S, 12.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CRCM-5484, CR-CM-5484, C-RCM-5484

IUPAC/Chemical Name

2-((7-Acetyl-3-(furan-2-ylmethyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)thio)-N-(2-methylpyridin-3-yl)acetamide

InChi Key

PQYXGDZAWKQEEM-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H23N5O4S2/c1-14-18(6-3-8-25-14)26-20(31)13-34-24-27-22-21(23(32)29(24)11-16-5-4-10-33-16)17-7-9-28(15(2)30)12-19(17)35-22/h3-6,8,10H,7,9,11-13H2,1-2H3,(H,26,31)

SMILES Code

O=C(NC1=CC=CN=C1C)CSC2=NC3=C(C4=C(CN(C(C)=O)CC4)S3)C(N2CC5=CC=CO5)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 509.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Carrasco K, Montersino C, Derviaux C, Saez-Ayala M, Hoffer L, Restouin A, Castellano R, Casassa J, Roche P, Pasquier E, Combes S, Morelli X, Collette Y, Betzi S. CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation. J Med Chem. 2022 Apr 14;65(7):5660-5674. doi: 10.1021/acs.jmedchem.1c02168. Epub 2022 Mar 29. PMID: 35348328.