RdRp inhibitor 11q is one of a series of novel aryl benzoyl hydrazide analogs as potent anti-influenza agents. It exhibited potent inhibitory activity against the avian H5N1 flu strain with EC50 values ranging from 0.009 to 0.034 μM. Moreover, compound 11q exhibited nanomolar antiviral effects against both the H1N1 virus and Flu B virus and possessed good oral bioavailability and inhibitory activity against influenza A virus in a mouse model.
MedKoo Cat#: 208319
Name: RdRp inhibitor 11q
CAS#: unknown
Chemical Formula: C17H17Br2N3O2
Exact Mass: 452.9688
Molecular Weight: 455.15
Elemental Analysis: C, 44.86; H, 3.76; Br, 35.11; N, 9.23; O, 7.03
The following data is based on the product molecular weight 455.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
