PROTAC CP17, is a novel purine-containing EGFR ligand, which was discovered as a highly potent degrader against EGFRL858R/T790M and EGFRdel19, reaching the lowest DC50 values among all reported EGFR-targeting PROTACs. Furthermore, CP17 exhibited excellent cellular activity against the H1975 and HCC827 cell lines with high selectivity
MedKoo Cat#: 208318
Name: PROTAC CP17
CAS#: unknown
Chemical Formula: C60H77N13O5S
Exact Mass: 1091.5891
Molecular Weight: 1092.42
Elemental Analysis: C, 65.97; H, 7.10; N, 16.67; O, 7.32; S, 2.93
The following data is based on the product molecular weight 1,092.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
