Synonym
MC-001, M-C001, MC00-1, N-Cystaminylbiguanide
IUPAC/Chemical Name
2-((2-Aminoethyl)disulfaneyl)ethyl-biguanide
InChi Key
NKYZZGZZRWZRGV-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H16N6S2/c7-1-3-13-14-4-2-11-6(10)12-5(8)9/h1-4,7H2,(H6,8,9,10,11,12)
SMILES Code
NCCSSCCNC(NC(N)=N)=N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
236.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fu J, Liu S, Hu M, Liao X, Wang X, Xu Z, Li Q, Quan J. Biguanide MC001, a Dual Inhibitor of OXPHOS and Glycolysis, Shows Enhanced Antitumor Activity Without Increasing Lactate Production. ChemMedChem. 2022 Mar 18;17(6):e202100674. doi: 10.1002/cmdc.202100674. Epub 2022 Jan 18. PMID: 34984842.
2: Xu B, Wang X, Xu Z, Li Q, Quan J. N-cystaminylbiguanide MC001 prevents neuron cell death and alleviates motor deficits in the MPTP-model of Parkinson's disease. Neurosci Lett. 2022 Jul 27;784:136751. doi: 10.1016/j.neulet.2022.136751. Epub 2022 Jun 20. PMID: 35738458.
3: Rojas-Lopez M, Martinelli M, Brandi V, Jubelin G, Polticelli F, Soriani M, Pizza M, Desvaux M, Rosini R. Identification of lipid A deacylase as a novel, highly conserved and protective antigen against enterohemorrhagic Escherichia coli. Sci Rep. 2019 Nov 19;9(1):17014. doi: 10.1038/s41598-019-53197-z. PMID: 31745113; PMCID: PMC6863877.
4: Perrot L, Charpentier M, Charpentier C, Feuillat M, Chassagne D. Yeast adapted to wine: nitrogen compounds released during induced autolysis in a model wine. J Ind Microbiol Biotechnol. 2002 Sep;29(3):134-9. doi: 10.1038/sj.jim.7000291. PMID: 12242635.
5: Barletta JF, Barletta GM, Brophy PD, Maxvold NJ, Hackbarth RM, Bunchman TE. Medication errors and patient complications with continuous renal replacement therapy. Pediatr Nephrol. 2006 Jun;21(6):842-5. doi: 10.1007/s00467-006-0049-y. Epub 2006 Apr 19. PMID: 16622714.
6: Rodriguez JA, Illas F. Activation of noble metals on metal-carbide surfaces: novel catalysts for CO oxidation, desulfurization and hydrogenation reactions. Phys Chem Chem Phys. 2012 Jan 14;14(2):427-38. doi: 10.1039/c1cp22738f. Epub 2011 Nov 23. PMID: 22108864.
7: Liu P, Rodriguez JA, Muckerman JT. The chemical activity of metal compound nanoparticles: importance of electronic and steric effects in M8C12 (M=Ti, V, Mo) metcars. J Chem Phys. 2004 Dec 1;121(21):10321-4. doi: 10.1063/1.1825374. PMID: 15549908.
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