MedKoo Cat#: 208299 | Name: DeMF1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DeMF1 is a mutant of recombinant mycobacterial subunit δ, which displays a unique N-terminal 111-amino acid extension. The successful targeting of the δ subunit demonstrates the potential to advance δ's flexible coupling as a new area for the development of F-ATP synthase inhibitors.

Chemical Structure

DeMF1
DeMF1
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208299

Name: DeMF1

CAS#: unknown

Chemical Formula: C28H24FNO3

Exact Mass: 441.1740

Molecular Weight: 441.50

Elemental Analysis: C, 76.17; H, 5.48; F, 4.30; N, 3.17; O, 10.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
De-MF1, DeMF-1, De-MF-1
IUPAC/Chemical Name
[(1R)-2-(1H-Indol-3-yl)-2-oxo-1-phenylethyl] 1-(3-fluorophenyl)cyclopentane-1-carboxylate
InChi Key
SIWJQHNCCWHAQY-AREMUKBSSA-N
InChi Code
InChI=1S/C28H24FNO3/c29-21-12-8-11-20(17-21)28(15-6-7-16-28)27(32)33-26(19-9-2-1-3-10-19)25(31)23-18-30-24-14-5-4-13-22(23)24/h1-5,8-14,17-18,26,30H,6-7,15-16H2/t26-/m1/s1
SMILES Code
O=C(C1(C2=CC=CC(F)=C2)CCCC1)O[C@H](C3=CC=CC=C3)C(C4=CNC5=C4C=CC=C5)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 441.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Harikishore A, Saw WG, Ragunathan P, Litty D, Dick T, Müller V, Grüber G. Mutational Analysis of Mycobacterial F-ATP Synthase Subunit δ Leads to a Potent δ Enzyme Inhibitor. ACS Chem Biol. 2022 Mar 18;17(3):529-535. doi: 10.1021/acschembio.1c00766. Epub 2022 Feb 11. PMID: 35148057.