F114 | CAS#uknown | Inhibitor

MedKoo Cat#: 208288 | Name: F114

Description:

WARNING: This product is for research use only, not for human or veterinary use.

F114 is a novel, first-in-class, dual aurora and lim kinase inhibitor. Using in vitro and ex vivo models of GBM, researchers found that F114 inhibits GBM proliferation and invasion. These results establish F114 as a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future drug development efforts for GBM, and potentially other cancers.

Chemical Structure

F114

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208288

Name: F114

CAS#: unknown

Chemical Formula: C16H20N6O

Exact Mass: 312.1699

Molecular Weight: 312.38

Elemental Analysis: C, 61.52; H, 6.45; N, 26.90; O, 5.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

F-114, F1-14, F11-4

IUPAC/Chemical Name

8-Isopropyl-2-((1-isopropyl-1H-pyrazol-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

InChi Key

WANOQCJEBRGYPS-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H20N6O/c1-10(2)21-9-13(8-18-21)19-16-17-7-12-5-6-14(23)22(11(3)4)15(12)20-16/h5-11H,1-4H3,(H,17,19,20)

SMILES Code

CC(C)N1N=CC(NC2=NC(N(C(C)C)C(C=C3)=O)=C3C=N2)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 312.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Charles TC, Newcomb W, Finan TM. ndvF, a novel locus located on megaplasmid pRmeSU47b (pEXO) of Rhizobium meliloti, is required for normal nodule development. J Bacteriol. 1991 Jul;173(13):3981-92. doi: 10.1128/jb.173.13.3981-3992.1991. PMID: 1648074; PMCID: PMC208044. 2: Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF. New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part II. Curr Drug Metab. 2009 Dec;10(10):1127-50. doi: 10.2174/138920009790820101. PMID: 20167000. 3: Rybin MJ, Laverde-Paz MJ, Suter RK, Affer M, Ayad NG, Feng Y, Zeier Z. A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion. Bioorg Med Chem Lett. 2022 Apr 1;61:128614. doi: 10.1016/j.bmcl.2022.128614. Epub 2022 Feb 10. PMID: 35151865. 4: Mosher CM, Hummel MA, Tracy TS, Rettie AE. Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9. Biochemistry. 2008 Nov 11;47(45):11725-34. doi: 10.1021/bi801231m. Epub 2008 Oct 16. PMID: 18922023; PMCID: PMC2713172. 5: Yadav SPS, Sandoval RM, Zhao J, Huang Y, Wang E, Kumar S, Campos-Bilderback SB, Rhodes G, Mechref Y, Molitoris BA, Wagner MC. Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance. Am J Physiol Renal Physiol. 2021 Jan 1;320(1):F114-F129. doi: 10.1152/ajprenal.00428.2020. Epub 2020 Dec 7. PMID: 33283642; PMCID: PMC7847050. 6: Zhou Z, Zhou Y, Yao Y, Qian J, Liu B, Yang Q, Shao C, Li H, Sun K, Tang Q, Xie J. A 16-plex Y-SNP typing system based on allele-specific PCR for the genotyping of Chinese Y-chromosomal haplogroups. Leg Med (Tokyo). 2020 Sep;46:101720. doi: 10.1016/j.legalmed.2020.101720. Epub 2020 May 30. PMID: 32505804. 7: Glass TR, Saiki H, Joh T, Taemi Y, Ohmura N, Lackie SJ. Evaluation of a compact bench top immunoassay analyzer for automatic and near continuous monitoring of a sample for environmental contaminants. Biosens Bioelectron. 2004 Sep 15;20(2):397-403. doi: 10.1016/j.bios.2004.02.011. PMID: 15308246. 8: Nie Y, Ke Y, Chen J, Ding M. [Construction of the full-length cDNA clone of Chinese virulent strain--F114]. Wei Sheng Wu Xue Bao. 2001 Aug;41(4):452-6. Chinese. PMID: 12552911. 9: Lee CC, Wang JW, Leu WM, Huang YT, Huang YW, Hsu YH, Meng M. Proliferating Cell Nuclear Antigen Suppresses RNA Replication of Bamboo Mosaic Virus through an Interaction with the Viral Genome. J Virol. 2019 Oct 29;93(22):e00961-19. doi: 10.1128/JVI.00961-19. PMID: 31511381; PMCID: PMC6819918. 10: Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE. Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding. Biochemistry. 1999 Mar 16;38(11):3285-92. doi: 10.1021/bi982161+. PMID: 10079071.