MedKoo Cat#: 208278 | Name: HS-276

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HS-276 is a potent and highly selective orally bioavailable TAK1 inhibitor.

Chemical Structure

HS-276
HS-276
CAS#2767422-72-8

Theoretical Analysis

MedKoo Cat#: 208278

Name: HS-276

CAS#: 2767422-72-8

Chemical Formula: C24H29N5O2

Exact Mass: 419.2321

Molecular Weight: 419.53

Elemental Analysis: C, 68.71; H, 6.97; N, 16.69; O, 7.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
HS-276, HS 276; HS276;
IUPAC/Chemical Name
N-(6-(Piperidin-1-ylmethyl)-1-propyl-1H-benzo[d]imidazol-2-yl)isophthalamide
InChi Key
NPEMHKSMWPZEOV-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H29N5O2/c1-2-11-29-21-14-17(16-28-12-4-3-5-13-28)9-10-20(21)26-24(29)27-23(31)19-8-6-7-18(15-19)22(25)30/h6-10,14-15H,2-5,11-13,16H2,1H3,(H2,25,30)(H,26,27,31)
SMILES Code
CCCN(C(NC(C1=CC(C(N)=O)=CC=C1)=O)=N2)C3=C2C=CC(CN4CCCCC4)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 419.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Scarneo S, Hughes P, Freeze R, Yang K, Totzke J, Haystead T. Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis. ACS Chem Biol. 2022 Mar 18;17(3):536-544. doi: 10.1021/acschembio.1c00788. Epub 2022 Mar 2. PMID: 35234444; PMCID: PMC9245008.