STING agonist C53 | CAS#2259624-71-8 | STING agonist

MedKoo Cat#: 112172 | Name: STING agonist C53

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

C53 is a STING agonist.

Chemical Structure

STING agonist C53

CAS#2259624-71-8

Theoretical Analysis

MedKoo Cat#: 112172

Name: STING agonist C53

CAS#: 2259624-71-8

Chemical Formula: C25H19ClF4N2O2

Exact Mass: 490.1071

Molecular Weight: 490.88

Elemental Analysis: C, 61.17; H, 3.90; Cl, 7.22; F, 15.48; N, 5.71; O, 6.52

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 Weeks
10mg	USD 585.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

C53; STING agonist C53, STING Agonist-12;

IUPAC/Chemical Name

1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide

InChi Key

OEBVYNULNKSONR-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H19ClF4N2O2/c1-25(2)17-7-6-13(23(33)31-11-15-20(29)9-14(27)10-21(15)30)8-22(17)32(24(25)34)12-16-18(26)4-3-5-19(16)28/h3-10H,11-12H2,1-2H3,(H,31,33)

SMILES Code

O=C(NCC1=C(C=C(C=C1F)F)F)C2=CC=C3C(N(C(C3(C)C)=O)CC4=C(C=CC=C4Cl)F)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMF	1.0	2.04
	DMSO	2.0	4.07

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 490.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chiannilkulchai N, Moenne A, Sentenac A, Mann C. Biochemical and genetic dissection of the Saccharomyces cerevisiae RNA polymerase C53 subunit through the analysis of a mitochondrially mis-sorted mutant construct. J Biol Chem. 1992 Nov 15;267(32):23099-107. PMID: 1429657. 2: Ream TS, Haag JR, Pontvianne F, Nicora CD, Norbeck AD, Paša-Tolić L, Pikaard CS. Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III-specific forms of the AC40 subunit and alternative forms of the C53 subunit. Nucleic Acids Res. 2015 Apr 30;43(8):4163-78. doi: 10.1093/nar/gkv247. Epub 2015 Mar 26. PMID: 25813043; PMCID: PMC4417161. 3: Hořejší B, Vinopal S, Sládková V, Dráberová E, Sulimenko V, Sulimenko T, Vosecká V, Philimonenko A, Hozák P, Katsetos CD, Dráber P. Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53. J Cell Physiol. 2012 Jan;227(1):367-82. doi: 10.1002/jcp.22772. PMID: 21465471. 4: Wu J, Jiang H, Luo S, Zhang M, Zhang Y, Sun F, Huang S, Li H. Caspase- mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope. Cell Res. 2013 May;23(5):691-704. doi: 10.1038/cr.2013.36. Epub 2013 Mar 12. PMID: 23478299; PMCID: PMC3641598. 5: Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM. Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53. Int J Mol Med. 2005 Aug;16(2):251-6. PMID: 16012757. 6: Jiang H, Luo S, Li H. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. J Biol Chem. 2005 May 27;280(21):20651-9. doi: 10.1074/jbc.M413431200. Epub 2005 Mar 24. PMID: 15790566. 7: Klebanovych A, Vinopal S, Dráberová E, Sládková V, Sulimenko T, Sulimenko V, Vosecká V, Macůrek L, Legido A, Dráber P. C53 Interacting with UFM1-Protein Ligase 1 Regulates Microtubule Nucleation in Response to ER Stress. Cells. 2022 Feb 5;11(3):555. doi: 10.3390/cells11030555. PMID: 35159364; PMCID: PMC8834445. 8: Lei Y, Liu H, Yang Y, Wang X, Ren N, Li B, Liu S, Cheng J, Fu X, Zhang J. Interaction of LHBs with C53 promotes hepatocyte mitotic entry: A novel mechanism for HBV-induced hepatocellular carcinoma. Oncol Rep. 2012 Jan;27(1):151-9. doi: 10.3892/or.2011.1489. Epub 2011 Oct 4. PMID: 21971960. 9: Wu J, Lei G, Mei M, Tang Y, Li H. A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem. 2010 May 14;285(20):15126-15136. doi: 10.1074/jbc.M110.110619. Epub 2010 Mar 12. PMID: 20228063; PMCID: PMC2865345. 10: Jiang H, Wu J, He C, Yang W, Li H. Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. Cell Res. 2009 Apr;19(4):458-68. doi: 10.1038/cr.2009.14. PMID: 19223857; PMCID: PMC2664857. 11: Kassavetis GA, Prakash P, Shim E. The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter opening. J Biol Chem. 2010 Jan 22;285(4):2695-706. doi: 10.1074/jbc.M109.074013. Epub 2009 Nov 24. PMID: 19940126; PMCID: PMC2807326. 12: Chen Y, Zheng Y, Iyer SR, Harders GE, Pan S, Chen HH, Ichiki T, Burnett JC Jr, Sangaralingham SJ. C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts. J Mol Cell Cardiol. 2019 May;130:140-150. doi: 10.1016/j.yjmcc.2019.03.024. Epub 2019 Apr 4. PMID: 30954448; PMCID: PMC6557127. 13: Stephani M, Picchianti L, Dagdas Y. C53 is a cross-kingdom conserved reticulophagy receptor that bridges the gap betweenselective autophagy and ribosome stalling at the endoplasmic reticulum. Autophagy. 2021 Feb;17(2):586-587. doi: 10.1080/15548627.2020.1846304. Epub 2020 Dec 3. PMID: 33164651; PMCID: PMC8007144.