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MedKoo Cat#: 208271 | Name: AMS-17

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMS-17 a rationally-designed tertiary sulfonylurea compound for inhibition of inflammation in microglia.

Chemical Structure

AMS-17
AMS-17
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208271

Name: AMS-17

CAS#: unknown

Chemical Formula: C15H13F3N4O3S

Exact Mass: 386.0660

Molecular Weight: 386.35

Elemental Analysis: Chemical Formula: C15H13F3N4O3S Exact Mass: 386.0660 Molecular Weight: 386.3492 Elemental Analysis: C, 46.63; H, 3.39; F, 14.75; N, 14.50; O, 12.42; S, 8.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
AMS17
IUPAC/Chemical Name
1-(Pyrimidin-5-yl)-3-((4-(trifluoromethyl)phenyl)sulfonyl)tetrahydropyrimidin-2(1H)-one
InChi Key
SNZNLNYLUJNKLC-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13F3N4O3S/c16-15(17,18)11-2-4-13(5-3-11)26(24,25)22-7-1-6-21(14(22)23)12-8-19-10-20-9-12/h2-5,8-10H,1,6-7H2
SMILES Code
O=C1N(S(=O)(C2=CC=C(C(F)(F)F)C=C2)=O)CCCN1C3=CN=CN=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 386.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Zhang C, Sajith AM, Xu X, Jiang J, Phillip Bowen J, Kulkarni A, Hao J. Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation. Bioorg Med Chem. 2022 Mar 15;58:116645. doi: 10.1016/j.bmc.2022.116645. Epub 2022 Jan 31. PMID: 35151118; PMCID: PMC8895276.

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CL-55

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