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MedKoo Cat#: 208267 | Name: CD22 glycan ligand

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CD22 glycan ligand, a member of Siglec family of sialic acid binding proteins, has restricted expression on B cells. Results suggest that natural killer cells modified with glycan ligands to CD22 and selectins promote both targeted killing of B lymphoma cells and improved trafficking to sites where the cancer cells reside, respectively.

Chemical Structure

CD22 glycan ligand
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208267

Name: CD22 glycan ligand

CAS#: unknown

Chemical Formula: C38H50FN3O20

Exact Mass: 887.2972

Molecular Weight: 887.82

Elemental Analysis: C, 51.41; H, 5.68; F, 2.14; N, 4.73; O, 36.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CD22 glycan-ligand, CD22-glycan ligand, CD22-glycan-ligand
IUPAC/Chemical Name
(2S,4S,5R,6R)-2-(((2R,3R,4R,5R,6R)-6-(((2R,3S,4R,5R,6R)-5-Acetamido-4-hydroxy-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-((1S,2R)-1,2-dihydroxy-3-(3-phenoxybenzamido)propyl)-5-(2-fluoroacetamido)-4-hydroxytetrahydro-2H-pyran-2-carboxylic acid
InChi Key
RSJBJZTYIOJZEI-FWZLTRJSSA-N
InChi Code
InChI=1S/C38H50FN3O20/c1-16(44)41-25-27(49)31(22(15-43)58-34(25)56-2)59-35-29(51)28(50)30(52)36(60-35)62-38(37(54)55)12-20(45)24(42-23(47)13-39)32(61-38)26(48)21(46)14-40-33(53)17-7-6-10-19(11-17)57-18-8-4-3-5-9-18/h3-11,20-22,24-32,34-36,43,45-46,48-52H,12-15H2,1-2H3,(H,40,53)(H,41,44)(H,42,47)(H,54,55)/t20-,21+,22+,24+,25+,26-,27+,28+,29+,30+,31+,32+,34+,35+,36+,38-/m0/s1
SMILES Code
O=C([C@@]1(O[C@@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H]3[C@@H](CO)O[C@@H](OC)[C@H](NC(C)=O)[C@H]3O)O2)C[C@H](O)[C@@H](NC(CF)=O)[C@H]([C@@H](O)[C@H](O)CNC(C4=CC=CC(OC5=CC=CC=C5)=C4)=O)O1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 887.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Hong S, Yu C, Wang P, Shi Y, Cao W, Cheng B, Chapla DG, Ma Y, Li J, Rodrigues E, Narimatsu Y, Yates JR 3rd, Chen X, Clausen H, Moremen KW, Macauley MS, Paulson JC, Wu P. Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-Cell Lymphoma Therapy. Angew Chem Int Ed Engl. 2021 Feb 15;60(7):3603-3610. doi: 10.1002/anie.202005934. Epub 2020 Dec 14. PMID: 33314603; PMCID: PMC7980786.