MedKoo Cat#: 208250 | Name: Chromenone 1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chromenone 1is a potent and selective inhibitor of MAO-A, with a 50% inhibitory concentration (IC50) of 2.70 μM and a selectivity index (SI) of 10.0 versus MAO-B. These results suggest that compounds 1 and 2 are reversible, competitive inhibitors of MAOs and can be considered potential therapies for neurological disorders such as depression and Alzheimer's disease

Chemical Structure

Chromenone 1
Chromenone 1
CAS#1639929-29-5

Theoretical Analysis

MedKoo Cat#: 208250

Name: Chromenone 1

CAS#: 1639929-29-5

Chemical Formula: C18H10F3N3O2

Exact Mass: 357.0725

Molecular Weight: 357.29

Elemental Analysis: C, 60.51; H, 2.82; F, 15.95; N, 11.76; O, 8.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Chromenone1, Chromenone-1
IUPAC/Chemical Name
2-(1H-1,2,4-Triazol-1-yl)-3-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one
InChi Key
KLOOVUXILKCLLC-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H10F3N3O2/c19-18(20,21)12-7-5-11(6-8-12)15-16(25)13-3-1-2-4-14(13)26-17(15)24-10-22-9-23-24/h1-10H
SMILES Code
O=C1C(C2=CC=C(C(F)(F)F)C=C2)=C(N3N=CN=C3)OC4=C1C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ahn S, Kim J, An S, Pyo JJ, Jung D, Lee J, Hwang SY, Gong J, Shin I, Kim HP, Kim H, Noh M. 2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore. Bioorg Med Chem. 2019 Jul 1;27(13):2948-2958. doi: 10.1016/j.bmc.2019.05.028. Epub 2019 May 17. PMID: 31128991. 2: Rastegari A, Nadri H, Mahdavi M, Moradi A, Mirfazli SS, Edraki N, Moghadam FH, Larijani B, Akbarzadeh T, Saeedi M. Design, synthesis and anti-Alzheimer's activity of novel 1,2,3-triazole-chromenone carboxamide derivatives. Bioorg Chem. 2019 Mar;83:391-401. doi: 10.1016/j.bioorg.2018.10.065. Epub 2018 Oct 30. PMID: 30412794. 3: Dai C, Xie Z, Qing X, Luo N, Wang C. DBU-mediated annulation of 2-aryl-3-nitro-2H-chromenes with 1,3-cyclohexanediones for the synthesis of benzofuro[2,3-c]chromenone derivatives. Mol Divers. 2020 Feb;24(1):191-200. doi: 10.1007/s11030-019-09939-2. Epub 2019 Mar 23. PMID: 30905029. 4: Oh JM, Lee C, Nam SJ, Kim H. Chromenone Derivatives as Monoamine Oxidase Inhibitors from Marine-Derived MAR4 Clade Streptomyces sp. CNQ-031. J Microbiol Biotechnol. 2021 Jul 28;31(7):1022-1027. doi: 10.4014/jmb.2105.05003. PMID: 34099598. 5: Ranatunga S, Tang CH, Kang CW, Kriss CL, Kloppenburg BJ, Hu CC, Del Valle JR. Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J Med Chem. 2014 May 22;57(10):4289-301. doi: 10.1021/jm5002452. Epub 2014 May 2. PMID: 24749861; PMCID: PMC4032190. 6: Deuther-Conrad W, Diez-Iriepa D, Iriepa I, López-Muñoz F, Martínez-Grau MA, Gütschow M, Marco-Contelles J. Studies on the affinity of 6-[(n-(cyclo)aminoalkyl)oxy]-4H-chromen-4-ones for sigma 1/2 receptors. RSC Med Chem. 2021 May 20;12(6):1000-1004. doi: 10.1039/d1md00105a. PMID: 34223165; PMCID: PMC8221265. 7: Karimi Askarani H, Iraji A, Rastegari A, Abbas Bukhari SN, Firuzi O, Akbarzadeh T, Saeedi M. Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease. BMC Chem. 2020 Oct 27;14(1):64. doi: 10.1186/s13065-020-00715-0. PMID: 33134975; PMCID: PMC7592376. 8: Boness HVM, de Oliveira MS, Batista CSC, Almeida LS, Boffo EF, Villarreal CF, Cruz FG. Anti-Inflammatory and Antinociceptive Properties of Kielmeyerone A, a Chromenone Isolated from the Roots of Kielmeyera reticulata. J Nat Prod. 2021 Aug 27;84(8):2157-2164. doi: 10.1021/acs.jnatprod.1c00157. Epub 2021 Jul 20. PMID: 34283606. 9: Esposito F, Ambrosio FA, Maleddu R, Costa G, Rocca R, Maccioni E, Catalano R, Romeo I, Eleftheriou P, Karia DC, Tsirides P, Godvani N, Pandya H, Corona A, Alcaro S, Artese A, Geronikaki A, Tramontano E. Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase- associated Ribonuclease H function and integrase activity. Eur J Med Chem. 2019 Nov 15;182:111617. doi: 10.1016/j.ejmech.2019.111617. Epub 2019 Aug 12. PMID: 31442684. 10: Wang Y, Kim JY, Song YH, Li ZP, Yoon SH, Uddin Z, Ban YJ, Lee KW, Park KH. Highly potent bacterial neuraminidase inhibitors, chromenone derivatives from Flemingia philippinensis. Int J Biol Macromol. 2019 May 1;128:149-157. doi: 10.1016/j.ijbiomac.2019.01.105. Epub 2019 Jan 23. PMID: 30682484.