MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 208236 | Name: HIV-1 inhibitor 9d

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HIV-1 inhibitor 9d

Chemical Structure

HIV-1 inhibitor 9d
HIV-1 inhibitor 9d
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208236

Name: HIV-1 inhibitor 9d

CAS#: unknown

Chemical Formula: C24H20N6

Exact Mass: 392.1749

Molecular Weight: 392.47

Elemental Analysis: C, 73.45; H, 5.14; N, 21.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
HIV1 inhibitor 9d, HIV-1-inhibitor 9d
IUPAC/Chemical Name
4-((4-((2,6-Dimethyl-4-(pyridin-4-yl)phenyl)amino)pyrimidin-2-yl)amino)benzonitrile
InChi Key
PAYRTWYMJYKBOL-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H20N6/c1-16-13-20(19-7-10-26-11-8-19)14-17(2)23(16)29-22-9-12-27-24(30-22)28-21-5-3-18(15-25)4-6-21/h3-14H,1-2H3,(H2,27,28,29,30)
SMILES Code
N#CC1=CC=C(NC2=NC=CC(NC3=C(C)C=C(C4=CC=NC=C4)C=C3C)=N2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 392.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Onywera H, Maman D, Inzaule S, Auma E, Were K, Fredrick H, Owiti P, Opollo V, Etard JF, Mukui I, Kim AA, Zeh C. Surveillance of HIV-1 pol transmitted drug resistance in acutely and recently infected antiretroviral drug-naïve persons in rural western Kenya. PLoS One. 2017 Feb 8;12(2):e0171124. doi: 10.1371/journal.pone.0171124. PMID: 28178281; PMCID: PMC5298248. 2: Adawaye C, Fokam J, Kamangu E, Alio HM, Chahad AM, Susin F, Moussa AM, Bertin TH, Tidjani A, Vaira D, Moutschen M. Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: findings from a cross-sectional study. BMC Res Notes. 2017 Nov 10;10(1):589. doi: 10.1186/s13104-017-2893-1. PMID: 29126456; PMCID: PMC5681824. 3: Forezi LDSM, Ribeiro MMJ, Marttorelli A, Abrantes JL, Rodrigues CR, Castro HC, Souza TML, Boechat FDCS, de Souza AMT, de Souza MCBV. Design, synthesis, in vitro and in silico studies of novel 4-oxoquinoline ribonucleoside derivatives as HIV-1 reverse transcriptase inhibitors. Eur J Med Chem. 2020 May 15;194:112255. doi: 10.1016/j.ejmech.2020.112255. Epub 2020 Mar 20. PMID: 32244098. 4: Pala N, Esposito F, Rogolino D, Carcelli M, Sanna V, Palomba M, Naesens L, Corona A, Grandi N, Tramontano E, Sechi M. Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities. Int J Mol Sci. 2016 Aug 20;17(8):1371. doi: 10.3390/ijms17081371. PMID: 27556447; PMCID: PMC5000766. 5: Devale TL, Parikh J, Miniyar P, Sharma P, Shrivastava B, Murumkar P. Dihydropyrimidinone-isatin hybrids as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorg Chem. 2017 Feb;70:256-266. doi: 10.1016/j.bioorg.2017.01.006. Epub 2017 Jan 18. PMID: 28160944. 6: Kang D, Ding X, Wu G, Huo Z, Zhou Z, Zhao T, Feng D, Wang Z, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP. ACS Med Chem Lett. 2017 Oct 19;8(11):1188-1193. doi: 10.1021/acsmedchemlett.7b00361. PMID: 29152052; PMCID: PMC5683699. 7: Ndembi N, Hamers RL, Sigaloff KC, Lyagoba F, Magambo B, Nanteza B, Watera C, Kaleebu P, Rinke de Wit TF. Transmitted antiretroviral drug resistance among newly HIV-1 diagnosed young individuals in Kampala. AIDS. 2011 Apr 24;25(7):905-10. doi: 10.1097/QAD.0b013e328346260f. PMID: 21399479. 8: Ragno R, Mai A, Sbardella G, Artico M, Massa S, Musiu C, Mura M, Marturana F, Cadeddu A, La Colla P. Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyri midin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C variant. J Med Chem. 2004 Feb 12;47(4):928-34. doi: 10.1021/jm0309856. PMID: 14761194. 9: Sigaloff KC, Mandaliya K, Hamers RL, Otieno F, Jao IM, Lyagoba F, Magambo B, Kapaata A, Ndembi N, Rinke de Wit TF. Short communication: High prevalence of transmitted antiretroviral drug resistance among newly HIV type 1 diagnosed adults in Mombasa, Kenya. AIDS Res Hum Retroviruses. 2012 Sep;28(9):1033-7. doi: 10.1089/AID.2011.0348. Epub 2012 Feb 2. PMID: 22149307. 10: Ma XD, Yang SQ, Gu SX, He QQ, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors. ChemMedChem. 2011 Dec 9;6(12):2225-32. doi: 10.1002/cmdc.201100334. Epub 2011 Sep 8. PMID: 21990112.