MedKoo Cat#: 208232 | Name: DPCPX

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DPCPX a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests

Chemical Structure

DPCPX
DPCPX
CAS#102146-07-6

Theoretical Analysis

MedKoo Cat#: 208232

Name: DPCPX

CAS#: 102146-07-6

Chemical Formula: C16H24N4O2

Exact Mass: 304.1899

Molecular Weight: 304.39

Elemental Analysis: C, 63.13; H, 7.95; N, 18.41; O, 10.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DP-CPX, DPC-PX
IUPAC/Chemical Name
8-Cyclopentyl-1,3-dipropylxanthine
InChi Key
FFBDFADSZUINTG-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
SMILES Code
O=C(N1CCC)N(CCC)C2=C(NC(C3CCCC3)=N2)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 304.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Szopa A, Poleszak E, Bogatko K, Wyska E, Wośko S, Doboszewska U, Świąder K, Wlaź A, Dudka J, Wróbel A, Wlaź P, Serefko A. DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1361-1371. doi: 10.1007/s00210-018-1551-z. Epub 2018 Aug 9. PMID: 30094458; PMCID: PMC6208968. 2: Coates J, Sheehan MJ, Strong P. 1,3-Dipropyl-8-cyclopentyl xanthine (DPCPX): a useful tool for pharmacologists and physiologists? Gen Pharmacol. 1994 May;25(3):387-94. doi: 10.1016/0306-3623(94)90185-6. PMID: 7926579. 3: Gao X, Hassan MM, Ghosh S, Mao G, Sankari A. Efficacy and toxicity of the DPCPX nanoconjugate drug study for the treatment of spinal cord injury in rats. J Appl Physiol (1985). 2022 Aug 1;133(2):262-272. doi: 10.1152/japplphysiol.00195.2022. Epub 2022 Jun 30. PMID: 35771225. 4: Bisserbe JC, Pascal O, Deckert J, Mazière B. Potential use of DPCPX as probe for in vivo localization of brain A1 adenosine receptors. Brain Res. 1992 Dec 18;599(1):6-12. doi: 10.1016/0006-8993(92)90845-z. PMID: 1493550. 5: Szopa A, Bogatko K, Serefko A, Wyska E, Wośko S, Świąder K, Doboszewska U, Wlaź A, Wróbel A, Wlaź P, Dudka J, Poleszak E. Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2A receptor antagonist, but not DPCPX, a selective adenosine A1 receptor antagonist. Pharmacol Rep. 2019 Aug;71(4):676-681. doi: 10.1016/j.pharep.2019.03.007. Epub 2019 Mar 16. PMID: 31200233. 6: Zhou Y, Tong L, Chu X, Deng F, Tang J, Tang Y, Dai Y. The Adenosine A1 Receptor Antagonist DPCPX Inhibits Tumor Progression via the ERK/JNK Pathway in Renal Cell Carcinoma. Cell Physiol Biochem. 2017;43(2):733-742. doi: 10.1159/000481557. Epub 2017 Sep 27. PMID: 28950257. 7: Kim JH, Kim JH, Kwon TH, Park YK, Chung HS. DPCPX-resistant hypoxic synaptic depression in the CA1 region of hippocampal slices: possible role of intracellular accumulation of monocarboxylates. Neurosci Lett. 2006 Jul 31;403(1-2):141-6. doi: 10.1016/j.neulet.2006.04.032. Epub 2006 May 22. PMID: 16714083. 8: Camara H, da Silva Junior ED, Garcia AG, Jurkiewicz A, Rodrigues JQD. Cardiac arrest induced by muscarinic or adenosine receptors agonists is reversed by DPCPX through double mechanism. Eur J Pharmacol. 2018 Jan 15;819:9-15. doi: 10.1016/j.ejphar.2017.09.030. Epub 2017 Sep 30. PMID: 28974348. 9: von der Leyen H, Schmitz W, Scholz H, Scholz J, Lohse MJ, Schwabe U. Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations. Naunyn Schmiedebergs Arch Pharmacol. 1989 Aug;340(2):204-9. doi: 10.1007/BF00168970. PMID: 2554151. 10: Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J Pharmacol Exp Ther. 2007 Feb;320(2):637-45. doi: 10.1124/jpet.106.111203. Epub 2006 Oct 31. PMID: 17077318.