HDAC6 inhibitor XP5 is a 2-phenylthiazole analogue synthesized as potential histone deacetylase 6 (HDAC6) inhibitors. Compound XP5 was the most potent HDAC6 inhibitor with an IC50 of 31 nM and excellent HDAC6 selectivity (SI = 338 for HDAC6 over HDAC3). XP5 also displayed high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50 = 0.16-2.31 μM),
MedKoo Cat#: 208225
Name: HDAC6 inhibitor XP5
CAS#: unknown
Chemical Formula: C19H25N3O5S
Exact Mass: 407.1515
Molecular Weight: 407.49
Elemental Analysis: C, 56.00; H, 6.18; N, 10.31; O, 19.63; S, 7.87
The following data is based on the product molecular weight 407.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
