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MedKoo Cat#: 208198 | Name: CO-Releasing agent 5

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CO-Releasing agent 5 is a chemical agent used to administer CO as an endogenous, biologically active molecule. In performance for both in vitro and in vivo experimental settings, it is proposes the mechanism of the CO release based on steady-state and transient spectroscopy experiments and quantum chemical calculations.

Chemical Structure

CO-Releasing agent 5
CO-Releasing agent 5
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208198

Name: CO-Releasing agent 5

CAS#: unknown

Chemical Formula: C20H13NO6

Exact Mass: 363.0743

Molecular Weight: 363.34

Elemental Analysis: C, 66.12; H, 3.61; N, 3.86; O, 26.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CO-Releasing agent5, COReleasing agent 5, COReleasingagent5
IUPAC/Chemical Name
4,4'-(9-Ethyl-9H-carbazole-3,6-diyl)bis(1,3-dioxol-2-one)
InChi Key
FRBIHFCYCPVYOQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H13NO6/c1-2-21-15-5-3-11(17-9-24-19(22)26-17)7-13(15)14-8-12(4-6-16(14)21)18-10-25-20(23)27-18/h3-10H,2H2,1H3
SMILES Code
CCN1C2=C(C3=C1C=CC(C4=COC(O4)=O)=C3)C=C(C5=COC(O5)=O)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 363.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Foresti R, Motterlini R. CO-releasing molecules: avoiding toxicity and exploiting the beneficial effects of CO for the treatment of cardiovascular disorders. Future Med Chem. 2013 Mar;5(4):367-9. doi: 10.4155/fmc.13.10. PMID: 23495681. 2: Kumar U, Ramakrishna B, Varghese J, Vidhyapriya P, Sakthivel N, Manimaran B. Self-Assembled Manganese(I)-Based Selenolato-Bridged Tetranuclear Metallorectangles: Host-Guest Interaction, Anticancer, and CO-Releasing Studies. Inorg Chem. 2021 Sep 6;60(17):13284-13298. doi: 10.1021/acs.inorgchem.1c01636. Epub 2021 Aug 6. PMID: 34357751. 3: Portal L, Morin D, Motterlini R, Ghaleh B, Pons S. The CO-releasing molecule CORM-3 protects adult cardiomyocytes against hypoxia-reoxygenation by modulating pH restoration. Eur J Pharmacol. 2019 Nov 5;862:172636. doi: 10.1016/j.ejphar.2019.172636. Epub 2019 Sep 3. PMID: 31491405. 4: Gong Y, Zhang T, Li M, Xi N, Zheng Y, Zhao Q, Chen Y, Liu B. Toxicity, bio- distribution and metabolism of CO-releasing molecules based on cobalt. Free Radic Biol Med. 2016 Aug;97:362-374. doi: 10.1016/j.freeradbiomed.2016.06.029. Epub 2016 Jun 30. PMID: 27375229. 5: Palao E, Slanina T, Muchová L, Šolomek T, Vítek L, Klán P. Transition-Metal- Free CO-Releasing BODIPY Derivatives Activatable by Visible to NIR Light as Promising Bioactive Molecules. J Am Chem Soc. 2016 Jan 13;138(1):126-33. doi: 10.1021/jacs.5b10800. Epub 2015 Dec 23. PMID: 26697725. 6: Zanellato I, Bonarrigo I, Ravera M, Gabano E, Gust R, Osella D. The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells. Metallomics. 2013 Dec;5(12):1604-13. doi: 10.1039/c3mt00117b. Epub 2013 Sep 9. PMID: 24057048. 7: Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M, Williamson MP, Henderson PJF, Poole RK. A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3. Redox Biol. 2018 Sep;18:114-123. doi: 10.1016/j.redox.2018.06.008. Epub 2018 Jun 30. PMID: 30007887; PMCID: PMC6067063. 8: Zimmermann A, Leffler CW, Tcheranova D, Fedinec AL, Parfenova H. Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure- induced neonatal vascular injury. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2501-7. doi: 10.1152/ajpheart.00354.2007. Epub 2007 Jul 13. PMID: 17630349. 9: Chlopicki S, Lomnicka M, Fedorowicz A, Grochal E, Kramkowski K, Mogielnicki A, Buczko W, Motterlini R. Inhibition of platelet aggregation by carbon monoxide-releasing molecules (CO-RMs): comparison with NO donors. Naunyn Schmiedebergs Arch Pharmacol. 2012 Jun;385(6):641-50. doi: 10.1007/s00210-012-0732-4. Epub 2012 Feb 25. PMID: 22362133; PMCID: PMC3349871. 10: Zhang T, Li M, Gong Y, Xi N, Zheng Y, Zhao Q, Chen Y, Liu B. Syntheses, properties and bio-activities of water-soluble CO-releasing molecule based on manganese. J Biol Inorg Chem. 2016 Oct;21(7):807-24. doi: 10.1007/s00775-016-1379-2. Epub 2016 Jul 27. PMID: 27465977.