Cathepsin X inhibitor Z9 | CAS# unknown | Inhibitor

MedKoo Cat#: 208181 | Name: Cathepsin X inhibitor Z9

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cathepsin X inhibitor Z9 significantly reduces tumor progression, both in vitro in cell-based functional assays and in vivo in two independent tumor mouse models: the FVB/PyMT transgenic and MMTV-PyMT orthotopic breast cancer mouse models. One of the mechanisms by which cathepsin X contributes to cancer progression is the compensation of cathepsin-B activity loss.

Chemical Structure

Cathepsin X inhibitor Z9

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208181

Name: Cathepsin X inhibitor Z9

CAS#: unknown

Chemical Formula: C15H17N3O3S

Exact Mass: 319.0991

Molecular Weight: 319.38

Elemental Analysis: C, 56.41; H, 5.37; N, 13.16; O, 15.03; S, 10.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Cathepsin-X inhibitor Z9, Cathepsin X-inhibitor Z9, Cathepsin X inhibitor-Z9

IUPAC/Chemical Name

1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2-((4-isopropyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one

InChi Key

MAPGFLOHGFHEOG-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H17N3O3S/c1-10(2)18-9-16-17-15(18)22-8-12(19)11-3-4-13-14(7-11)21-6-5-20-13/h3-4,7,9-10H,5-6,8H2,1-2H3

SMILES Code

O=C(C1=CC=C2OCCOC2=C1)CSC3=NN=CN3C(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 319.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fonović UP, Knez D, Hrast M, Zidar N, Proj M, Gobec S, Kos J. Structure- activity relationships of triazole-benzodioxine inhibitors of cathepsin X. Eur J Med Chem. 2020 May 1;193:112218. doi: 10.1016/j.ejmech.2020.112218. Epub 2020 Mar 12. PMID: 32208223. 2: Mitrović A, Završnik J, Mikhaylov G, Knez D, Pečar Fonović U, Matjan Štefin P, Butinar M, Gobec S, Turk B, Kos J. Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy. Cell Mol Life Sci. 2022 Jan 6;79(1):34. doi: 10.1007/s00018-021-04117-w. PMID: 34989869; PMCID: PMC8738504. 3: Jakoš T, Pišlar A, Pečar Fonović U, Švajger U, Kos J. Cysteine cathepsins L and X differentially modulate interactions between myeloid-derived suppressor cells and tumor cells. Cancer Immunol Immunother. 2020 Sep;69(9):1869-1880. doi: 10.1007/s00262-020-02592-x. Epub 2020 May 5. PMID: 32372139.